VSIG4

Gene Information

Official Symbol: VSIG4
Official Name: V-set and immunoglobulin domain containing 4
Aliases and Previous Symbols: N/A
Entrez ID: 11326
UniProt: Q9Y279
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
UniProt Summary: Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases. {ECO:0000269|PubMed:17016562, ECO:0000269|PubMed:17051150}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16970
Expression level (log2 read counts): -7.68

Expression Distribution

ig
V-set
I-set

regulation of complement activation, alternative pathway
negative regulation of complement activation, alternative pathway
complement component C3b binding
negative regulation of complement activation
negative regulation of humoral immune response
complement activation, alternative pathway
negative regulation of macrophage activation
negative regulation of interleukin-2 production
regulation of macrophage activation
regulation of interleukin-2 production
negative regulation of innate immune response
negative regulation of T cell proliferation
negative regulation of lymphocyte proliferation
negative regulation of mononuclear cell proliferation
negative regulation of leukocyte proliferation
negative regulation of response to biotic stimulus
negative regulation of T cell activation
regulation of complement activation
negative regulation of immune effector process
negative regulation of leukocyte cell-cell adhesion
regulation of humoral immune response
negative regulation of lymphocyte activation
negative regulation of immune response
regulation of T cell proliferation
negative regulation of leukocyte activation
negative regulation of cell-cell adhesion
complement activation
negative regulation of cell activation
negative regulation of defense response
regulation of lymphocyte proliferation
regulation of mononuclear cell proliferation
negative regulation of multi-organism process
regulation of leukocyte proliferation
negative regulation of cell adhesion
negative regulation of cytokine production
regulation of leukocyte cell-cell adhesion
regulation of T cell activation
humoral immune response
negative regulation of response to external stimulus
regulation of cell-cell adhesion