VWF
Gene Information
- Official Symbol: VWF
- Official Name: von Willebrand factor
- Aliases and Previous Symbols: N/A
- Entrez ID: 7450
- UniProt: P04275
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large multimeric complexes. These complexes function in the adhesion of platelets to sites of vascular injury and the transport of various proteins in the blood. Mutations in this gene result in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Oct 2015].
- UniProt Summary: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 12049
- Expression level (log2 read counts): -4.01
VWF Expression in NALM6 Cells: -4.01
