WASF3

Entrez Summary: N/A
UniProt Summary: Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:21834987}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Calcipotriol 5μM R08 exp464	-1.75
Hypoxia 5%O2 R04 exp191	-1.74

modification of postsynaptic actin cytoskeleton
modification of postsynaptic structure
modification of synaptic structure
positive regulation of myelination
actin filament polymerization
lamellipodium assembly
oligodendrocyte development
regulation of myelination
lamellipodium organization
actin polymerization or depolymerization
positive regulation of nervous system process
oligodendrocyte differentiation
postsynapse
protein polymerization
glial cell development
regulation of nervous system process
regulation of cell shape
glial cell differentiation
lamellipodium
gliogenesis
actin filament organization
actin binding
synapse organization
glutamatergic synapse
cytoskeleton
plasma membrane bounded cell projection assembly
supramolecular fiber organization
cell projection assembly
regulation of cell morphogenesis
actin cytoskeleton organization
positive regulation of nervous system development
actin filament-based process
regulation of system process
cellular protein-containing complex assembly
regulation of nervous system development
central nervous system development
regulation of anatomical structure morphogenesis
cytoskeleton organization
plasma membrane bounded cell projection organization
cell projection organization