WASL
Gene Information
- Official Symbol: WASL
- Official Name: WASP like actin nucleation promoting factor
- Aliases and Previous Symbols: N/A
- Entrez ID: 8976
- UniProt: O00401
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. Plays a role in dendrite spine morphogenesis (By similarity). {ECO:0000250|UniProtKB:Q91YD9, ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:19487689, ECO:0000269|PubMed:22847007, ECO:0000269|PubMed:22921828}.
Pfam Domains GO Terms
Pfam Domains
| WH2 |
| PBD |
| WH1 |
GO Terms
| negative regulation of membrane tubulation |
| actin cap |
| positive regulation of clathrin-dependent endocytosis |
| vesicle transport along actin filament |
| actin cortical patch organization |
| actin cortical patch assembly |
| regulation of membrane tubulation |
| actin cortical patch localization |
| actin filament-based transport |
| positive regulation of Arp2/3 complex-mediated actin nucleation |
| GTPase regulator activity |
| negative regulation of lymphocyte migration |
| regulation of plasma membrane organization |
| positive regulation of actin nucleation |
| regulation of Arp2/3 complex-mediated actin nucleation |
| actin cortical patch |
| regulation of clathrin-dependent endocytosis |
| dendritic spine morphogenesis |
| cellular protein-containing complex localization |
| regulation of actin nucleation |
| dendritic spine development |
| positive regulation of filopodium assembly |
| dendritic spine organization |
| actin filament polymerization |
| neuron projection organization |
| cortical actin cytoskeleton organization |
| regulation of nitric-oxide synthase activity |
| regulation of filopodium assembly |
| negative regulation of leukocyte migration |
| cortical cytoskeleton organization |
| spindle localization |
| vesicle cytoskeletal trafficking |
| actin polymerization or depolymerization |
| positive regulation of receptor-mediated endocytosis |
| regulation of monooxygenase activity |
| dendrite morphogenesis |
| regulation of lymphocyte migration |
| endocytic vesicle membrane |
| actin filament |
| ephrin receptor signaling pathway |
| protein polymerization |
| postsynapse organization |
| positive regulation of actin filament polymerization |
| regulation of oxidoreductase activity |
| vesicle budding from membrane |
| regulation of receptor-mediated endocytosis |
| positive regulation of endocytosis |
| positive regulation of plasma membrane bounded cell projection assembly |
| dendrite development |
| actin filament-based movement |
| positive regulation of protein polymerization |
| Fc-gamma receptor signaling pathway involved in phagocytosis |
| immune response-regulating cell surface receptor signaling pathway involved in phagocytosis |
| Fc receptor mediated stimulatory signaling pathway |
| Fc-gamma receptor signaling pathway |
| regulation of actin filament polymerization |
| establishment of vesicle localization |
| cytoskeleton-dependent intracellular transport |
| lamellipodium |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| vesicle localization |
| regulation of leukocyte migration |
| positive regulation of supramolecular fiber organization |
| regulation of plasma membrane bounded cell projection assembly |
| regulation of cell projection assembly |
| actin filament binding |
| regulation of endocytosis |
| actin cytoskeleton |
| positive regulation of cytoskeleton organization |
| regulation of protein polymerization |
| actin filament organization |
| Fc receptor signaling pathway |
| positive regulation of protein complex assembly |
| cytoplasmic vesicle |
| protein-containing complex localization |
| negative regulation of cell migration |
| regulation of actin filament organization |
| synapse organization |
| negative regulation of cell motility |
| vesicle organization |
| negative regulation of cellular component movement |
| negative regulation of locomotion |
| phagocytosis |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| establishment of organelle localization |
| regulation of cellular component size |
| positive regulation of cell projection organization |
| regulation of actin filament-based process |
| cell morphogenesis involved in neuron differentiation |
| negative regulation of immune system process |
| immune response-activating cell surface receptor signaling pathway |
| regulation of protein complex assembly |
| supramolecular fiber organization |
| neuron projection morphogenesis |
| immune response-regulating cell surface receptor signaling pathway |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| cell division |
| actin cytoskeleton organization |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| cell part morphogenesis |
| regulation of anatomical structure size |
| positive regulation of cellular component biogenesis |
| regulation of cytoskeleton organization |
| regulation of vesicle-mediated transport |
| endocytosis |
| cell morphogenesis involved in differentiation |
| immune response-activating signal transduction |
| actin filament-based process |
| organelle localization |
| immune response-regulating signaling pathway |
| positive regulation of organelle organization |
| activation of immune response |
| neuron projection development |
| import into cell |
| response to bacterium |
| regulation of plasma membrane bounded cell projection organization |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| enzyme linked receptor protein signaling pathway |
| cell morphogenesis |
| neuron development |
| cellular component morphogenesis |
| cellular protein-containing complex assembly |
| regulation of cell migration |
| membrane organization |
| positive regulation of immune response |
| regulation of cell motility |
| regulation of cellular component biogenesis |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| cell cycle process |
| neuron differentiation |
| regulation of protein localization |
| immune effector process |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| regulation of immune response |
| positive regulation of immune system process |
| cell projection organization |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| cell cycle |
| intracellular transport |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| movement of cell or subcellular component |
| protein-containing complex assembly |
| cellular protein localization |
| cellular macromolecule localization |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| regulation of immune system process |
| positive regulation of RNA metabolic process |
| establishment of localization in cell |
| protein-containing complex subunit organization |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| vesicle-mediated transport |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11886
- Expression level (log2 read counts): 3.11
Expression Distribution
WASL Expression in NALM6 Cells: 3.11
