WBP2

Gene Information

Official Symbol: WBP2
Official Name: WW domain binding protein 2
Aliases and Previous Symbols: N/A
Entrez ID: 23558
UniProt: Q969T9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation (PubMed:16772533). In presence of estrogen, binds to ESR1- responsive promoters (PubMed:16772533). Required for YAP1 coactivation function on PGR activity (PubMed:16772533). Synergizes with WBP2 in enhancing PGR activity (PubMed:16772533). Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By similarity). {ECO:0000250|UniProtKB:P97765, ECO:0000269|PubMed:16772533}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7730
Expression level (log2 read counts): 5.39

Expression Distribution

WWbp
GRAM

positive regulation of histone H3-K14 acetylation
regulation of histone H3-K14 acetylation
progesterone receptor signaling pathway
positive regulation of intracellular estrogen receptor signaling pathway
positive regulation of intracellular steroid hormone receptor signaling pathway
cellular response to estrogen stimulus
positive regulation of histone acetylation
positive regulation of peptidyl-lysine acetylation
regulation of intracellular estrogen receptor signaling pathway
positive regulation of protein acetylation
estrogen receptor binding
response to progesterone
regulation of histone acetylation
regulation of peptidyl-lysine acetylation
positive regulation of gene expression, epigenetic
intracellular steroid hormone receptor signaling pathway
regulation of protein acetylation
chromatin DNA binding
response to estrogen
regulation of intracellular steroid hormone receptor signaling pathway
positive regulation of histone modification
positive regulation of chromatin organization
steroid hormone mediated signaling pathway
regulation of histone modification
intracellular receptor signaling pathway
hormone-mediated signaling pathway
positive regulation of chromosome organization
cellular response to steroid hormone stimulus
regulation of chromatin organization
response to ketone
regulation of gene expression, epigenetic
nuclear chromatin
transcription coactivator activity
response to steroid hormone
regulation of chromosome organization
RNA polymerase II proximal promoter sequence-specific DNA binding
cellular response to lipid
cellular response to organic cyclic compound
cellular response to hormone stimulus
positive regulation of organelle organization