WBP2NL

Entrez Summary: N/A
UniProt Summary: May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

GRAM
WWbp

perinuclear theca
female pronucleus assembly
male pronucleus assembly
egg activation
sperm head
WW domain binding
sperm flagellum
chromatin DNA binding
nucleus organization
single fertilization
fertilization
meiotic cell cycle
transcription coactivator activity
regulation of cytosolic calcium ion concentration
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
cellular metal ion homeostasis
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis
organelle assembly
ion homeostasis
sexual reproduction
cellular homeostasis
multi-organism reproductive process
cell activation
chemical homeostasis
cell cycle
reproductive process
reproduction
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
homeostatic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process