WBSCR22 [The Human Chemical-Genetic Interaction Map Project]

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======= WBSCR22 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BUD23
  * **<color #00a2e8>Official Name</color>**: BUD23 rRNA methyltransferase and ribosome maturation factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=114049|114049]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43709|O43709]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WBSCR22&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WBSCR22|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615733|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA (PubMed:25851604). Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity (PubMed:25851604). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity (PubMed:25851604). Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity (PubMed:24086612). Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors (PubMed:24488492). Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements (PubMed:24488492). Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro (PubMed:24488492). {ECO:0000250, ECO:0000269|PubMed:24086612, ECO:0000269|PubMed:24488492, ECO:0000269|PubMed:25851604}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WBS methylT|
|Methyltransf 11|
|Methyltransf 18|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|rRNA (guanine-N7)-methylation|
|rRNA (guanine) methyltransferase activity|
|RNA (guanine-N7)-methylation|
|positive regulation of rRNA processing|
|positive regulation of ribosome biogenesis|
|rRNA base methylation|
|regulation of rRNA processing|
|regulation of ribosome biogenesis|
|rRNA methylation|
|rRNA modification|
|methyltransferase activity|
|RNA methylation|
|RNA modification|
|rRNA processing|
|rRNA metabolic process|
|macromolecule methylation|
|ribosome biogenesis|
|methylation|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|protein heterodimerization activity|
|positive regulation of cellular component biogenesis|
|perinuclear region of cytoplasm|
|chromatin organization|
|nucleolus|
|RNA processing|
|regulation of cellular component biogenesis|
|chromosome organization|
|RNA binding|
|RNA metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.88|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.72|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.72|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.72|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|1.81|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.83|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.84|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.84|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|1.87|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.98|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2|
|[[:results:exp149|SB203580 25μM R03 exp149]]|2.04|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.11|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|2.15|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 720/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|25/25|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|19/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 325
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WBSCR22 Expression in NALM6 Cells: 6.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>