WBSCR22

Entrez Summary: N/A
UniProt Summary: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA (PubMed:25851604). Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity (PubMed:25851604). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity (PubMed:25851604). Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity (PubMed:24086612). Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors (PubMed:24488492). Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements (PubMed:24488492). Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro (PubMed:24488492). {ECO:0000250, ECO:0000269|PubMed:24086612, ECO:0000269|PubMed:24488492, ECO:0000269|PubMed:25851604}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.05μM R00 exp7	-1.88
MLN-4924 2μM R00 exp22	-1.72
Cyclosporin-A 3μM R07 exp348	1.72
∆-9-Tetrahydrocannabinol 30μM R08 exp445	1.72
Bisphenol S 100μM R08 exp458	1.81
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	1.83
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.84
NMS-873 0.07μM R07 exp380	1.84
Alda-1 10μM R06 exp262	1.87
IU1-C 25μM R04 exp183	1.98
THZ531 0.11 to 0.175μM on day4 R07 exp413	2
SB203580 25μM R03 exp149	2.04
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	2.11
Nicotinate 1000μM R03 exp140	2.15
ABT-702 5μM R07 exp318	2.23

Global Fraction of Cell Lines Where Essential: 720/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	27/28
bone	25/25
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	16/17
esophagus	13/13
fibroblast	1/1
gastric	15/15
kidney	19/21
liver	20/20
lung	75/75
lymphocyte	14/14
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	23/24
soft tissue	7/7
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

rRNA (guanine-N7)-methylation
rRNA (guanine) methyltransferase activity
RNA (guanine-N7)-methylation
positive regulation of rRNA processing
positive regulation of ribosome biogenesis
rRNA base methylation
regulation of rRNA processing
regulation of ribosome biogenesis
rRNA methylation
rRNA modification
methyltransferase activity
RNA methylation
RNA modification
rRNA processing
rRNA metabolic process
macromolecule methylation
ribosome biogenesis
methylation
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
protein heterodimerization activity
positive regulation of cellular component biogenesis
perinuclear region of cytoplasm
chromatin organization
nucleolus
RNA processing
regulation of cellular component biogenesis
chromosome organization
RNA binding
RNA metabolic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of gene expression
gene expression