WDR20 [The Human Chemical-Genetic Interaction Map Project]

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======= WDR20 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDR20
  * **<color #00a2e8>Official Name</color>**: WD repeat domain 20
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=91833|91833]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TBZ3|Q8TBZ3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDR20&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDR20|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617741|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein deubiquitination|
|protein modification by small protein removal|
|protein modification by small protein conjugation or removal|
|proteolysis|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-3.27|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.77|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2.56|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-2.45|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-2.41|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.41|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.25|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-2.12|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-2.09|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.07|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-2.06|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-2.02|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-2.02|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2.02|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-1.92|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.89|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.81|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.79|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.75|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.75|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.8|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.89|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.92|
|[[:results:exp539|42°C R08 exp539]]|1.96|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.99|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.26|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.41|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.48|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|2.65|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.82|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.88|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:w:wdr48|WDR48]]|0.571|
|[[:human genes:u:usp46|USP46]]|0.524|
|[[:human genes:p:phlpp1|PHLPP1]]|0.473|
|[[:human genes:b:b3gnt2|B3GNT2]]|0.456|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3361
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDR20 Expression in NALM6 Cells: 4.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>