WDR20

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
TRAIL 5ng/ml R00 exp35	-3.27
TRAIL 50ng/ml R00 exp36	-2.77
Nicotine 3000μM R08 exp510	-2.56
PF-06409577 20μM R07 exp389	-2.45
VER-155008 3.9μM R06 exp301	-2.41
Wortmannin 5μM R00 exp38	-2.41
THZ531 0.11 to 0.175μM on day4 R07 exp413	-2.25
Azithromycin 100μM R08 exp452	-2.12
CCT251545 20μM R07 exp326	-2.09
ABT-702 5μM plus CoCl2 18μM R07 exp320	-2.07
Curcumin 6.5μM R06 exp277	-2.06
NMS-873 0.07μM R07 exp380	-2.02
SB202190 10μM R03 exp148	-2.02
THZ531 0.11μM R07 exp409	-2.02
6-Thio-2-deoxyguanosine 2μM R06 exp259	-1.92
Trimetrexate 0.03μM R08 exp535	-1.89
Wortmannin 0.5μM R00 exp37	-1.81
EPZ-5676 30μM R05 exp233	-1.79
Senexin-A 25μM R07 exp400	-1.75
Ammonium tetrathiomolybdate 10μM R08 exp448	1.75
Dimethyloxaloylglycine 100μM R05 exp229	1.8
Cryptotanshinone 12μM R05 exp227	1.89
Aminopterin 0.005μM R07 exp335	1.92
42°C R08 exp539	1.96
Aphidicolin 0.4μM R08 exp440	1.99
Hippuristanol 0.12μM R08 exp488	2.26
Olaparib 4μM R08 exp512	2.41
Thapsigargin 0.005μM R07 exp407	2.48
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	2.65
3-Bromopyruvate 7μM R04 exp175	2.82
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.88
Amiloride 100μM R08 exp447	2.97

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein deubiquitination
protein modification by small protein removal
protein modification by small protein conjugation or removal
proteolysis