WDR44

Entrez Summary: This gene encodes a protein that interacts with the small GTPase rab11. A similar protein in rat binds the GTP-containing active form of rab11. This protein may play a role in endosome recycling. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cannabidiol 13μM R08 exp465	-2.78
proTAME 5μM R04 exp187	-1.81
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.72
Tanespimycin 14μM R08 exp527	1.84

Global Fraction of Cell Lines Where Essential: 10/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	3/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	1/18
liver	0/19
lung	0/72
lymphocyte	1/16
ovary	1/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	1/12
prostate	0/1
skin	1/20
soft tissue	0/9
thyroid	1/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Rab GTPase binding
endosome membrane
perinuclear region of cytoplasm
Golgi apparatus