WDR46 [The Human Chemical-Genetic Interaction Map Project]

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======= WDR46 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDR46
  * **<color #00a2e8>Official Name</color>**: WD repeat domain 46
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9277|9277]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15213|O15213]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDR46&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDR46|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611440|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus. {ECO:0000269|PubMed:23848194}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BING4CT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|small-subunit processome|
|maturation of SSU-rRNA|
|ribosomal small subunit biogenesis|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|ncRNA processing|
|cellular component|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|nucleolus|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-2.01|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|1.7|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.71|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.87|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|1.89|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|2.07|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|2.15|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|2.27|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|2.31|
|[[:results:exp331|A-769662 20μM R07 exp331]]|2.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:o:or11h6|OR11H6]]|0.443|
|[[:human genes:c:cbwd5|CBWD5]]|0.43|
|[[:human genes:b:brix1|BRIX1]]|0.426|
|[[:human genes:c:cbwd3|CBWD3]]|0.42|
|[[:human genes:r:rpl35|RPL35]]|0.419|
|[[:human genes:b:bysl|BYSL]]|0.416|
|[[:human genes:c:cbwd6|CBWD6]]|0.414|
|[[:human genes:p:pole|POLE]]|0.409|
|[[:human genes:r:rbbp5|RBBP5]]|0.408|
|[[:human genes:s:s1pr4|S1PR4]]|0.406|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.405|
|[[:human genes:m:myo1h|MYO1H]]|0.405|
|[[:human genes:c:chd4|CHD4]]|0.404|
|[[:human genes:s:stil|STIL]]|0.404|
|[[:human genes:r:rad51|RAD51]]|0.402|
|[[:human genes:c:cdc73|CDC73]]|0.4|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 103/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|7/28|
|blood|1/28|
|bone|6/26|
|breast|3/33|
|central nervous system|3/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|6/21|
|liver|1/20|
|lung|12/75|
|lymphocyte|3/16|
|ovary|1/26|
|pancreas|7/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|7/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1803
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDR46 Expression in NALM6 Cells: 6.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>