WDR46

Entrez Summary: N/A
UniProt Summary: Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus. {ECO:0000269|PubMed:23848194}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-6727 0.04μM R03 exp98	-2.01
Wiskostatin 3μM R07 exp422	1.7
PF-06409577 20μM R07 exp389	1.71
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.87
Alda-1 10μM R06 exp262	1.89
FBS-Wisent 0.1 R07 exp426	2.07
BI-D1870 2μM R04 exp162	2.15
Cidofovir 10μM R07 exp345	2.27
Cyclosporin-A 3μM R07 exp348	2.31
A-769662 20μM R07 exp331	2.42

Global Fraction of Cell Lines Where Essential: 103/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	7/28
blood	1/28
bone	6/26
breast	3/33
central nervous system	3/56
cervix	1/4
colorectal	3/17
esophagus	2/13
fibroblast	0/1
gastric	2/16
kidney	6/21
liver	1/20
lung	12/75
lymphocyte	3/16
ovary	1/26
pancreas	7/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	5/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	7/22
urinary tract	3/29
uterus	0/5

Expression Distribution

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
small-subunit processome
maturation of SSU-rRNA
ribosomal small subunit biogenesis
rRNA processing
rRNA metabolic process
ribosome biogenesis
ncRNA processing
cellular component
ribonucleoprotein complex biogenesis
ncRNA metabolic process
nucleolus
RNA processing
RNA binding
RNA metabolic process
gene expression