WDR81

Entrez Summary: This gene encodes a multi-domain transmembrane protein which is predominantly expressed in the brain and is thought to play a role in endolysosomal trafficking. Mutations in this gene are associated with an autosomal recessive form of a syndrome exhibiting cerebellar ataxia, cognitive disability, and disequilibrium (CAMRQ2). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

WD40
Beach

phosphatidylinositol 3-kinase regulator activity
aggrephagy
extrinsic component of endosome membrane
selective autophagy
early endosome to late endosome transport
K63-linked polyubiquitin modification-dependent protein binding
vesicle-mediated transport between endosomal compartments
autophagosome membrane
regulation of phosphatidylinositol 3-kinase activity
regulation of lipid kinase activity
regulation of phospholipid metabolic process
negative regulation of phosphatase activity
negative regulation of dephosphorylation
late endosome membrane
cytosolic transport
early endosome membrane
macroautophagy
regulation of phosphatase activity
protein stabilization
regulation of dephosphorylation
autophagy
process utilizing autophagic mechanism
regulation of protein stability
lysosomal membrane
regulation of lipid metabolic process
mitochondrion organization
negative regulation of hydrolase activity
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
negative regulation of catalytic activity
regulation of kinase activity
cellular macromolecule catabolic process
endoplasmic reticulum membrane
regulation of transferase activity