WFIKKN1

Gene Information

Official Symbol: WFIKKN1
Official Name: WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
Aliases and Previous Symbols: N/A
Entrez ID: 117166
UniProt: Q96NZ8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12753
Expression level (log2 read counts): -1.73

Expression Distribution

Screen	Score
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-1.79
ML-792 0.2μM R08 exp505	1.74

V-set
WAP
Kunitz BPTI
I-set
Kazal 2

metalloendopeptidase inhibitor activity
transforming growth factor beta binding
receptor antagonist activity
negative regulation of signaling receptor activity
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of cellular response to transforming growth factor beta stimulus
serine-type endopeptidase inhibitor activity
regulation of transforming growth factor beta receptor signaling pathway
regulation of cellular response to transforming growth factor beta stimulus
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
negative regulation of cellular response to growth factor stimulus
regulation of signaling receptor activity
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
negative regulation of endopeptidase activity
negative regulation of peptidase activity
regulation of cellular response to growth factor stimulus
negative regulation of proteolysis
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
regulation of proteolysis
negative regulation of catalytic activity
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
negative regulation of signal transduction
regulation of hydrolase activity
negative regulation of cell communication
negative regulation of signaling
negative regulation of response to stimulus
extracellular region