WIPF2

Entrez Summary: N/A
UniProt Summary: Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. {ECO:0000269|PubMed:11829459, ECO:0000269|PubMed:12213210}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

actin cortical patch assembly
actin cortical patch organization
actin cortical patch localization
actin cortical patch
cortical actin cytoskeleton organization
cortical cytoskeleton organization
actin filament
actin filament-based movement
Fc-gamma receptor signaling pathway involved in phagocytosis
immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
Fc receptor mediated stimulatory signaling pathway
Fc-gamma receptor signaling pathway
actin filament binding
Fc receptor signaling pathway
phagocytosis
immune response-activating cell surface receptor signaling pathway
immune response-regulating cell surface receptor signaling pathway
actin cytoskeleton organization
endocytosis
immune response-activating signal transduction
actin filament-based process
immune response-regulating signaling pathway
activation of immune response
import into cell
positive regulation of immune response
immune effector process
cytoskeleton organization
regulation of immune response
positive regulation of immune system process
movement of cell or subcellular component
regulation of immune system process
vesicle-mediated transport