WISP1

Entrez Summary: N/A
UniProt Summary: Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan. {ECO:0000269|PubMed:10716946, ECO:0000269|PubMed:11782444}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

insulin-like growth factor binding
negative regulation of chondrocyte differentiation
negative regulation of cartilage development
positive regulation of smooth muscle cell migration
osteoclast differentiation
negative regulation of fat cell differentiation
regulation of chondrocyte differentiation
positive regulation of wound healing
positive regulation of osteoblast differentiation
regulation of smooth muscle cell migration
positive regulation of response to wounding
regulation of cartilage development
positive regulation of ossification
positive regulation of smooth muscle cell proliferation
myeloid leukocyte differentiation
regulation of osteoblast differentiation
regulation of fat cell differentiation
osteoblast differentiation
integrin binding
regulation of smooth muscle cell proliferation
regulation of wound healing
positive regulation of inflammatory response
regulation of response to wounding
heparin binding
positive regulation of Wnt signaling pathway
glucose homeostasis
carbohydrate homeostasis
regulation of ossification
bone development
regulation of cytokine secretion
myeloid cell differentiation
extracellular matrix
ossification
leukocyte differentiation
regulation of inflammatory response
cell-cell signaling by wnt
Wnt signaling pathway
regulation of Wnt signaling pathway
cell surface receptor signaling pathway involved in cell-cell signaling
regulation of protein secretion