WLS [The Human Chemical-Genetic Interaction Map Project]

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======= WLS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WLS
  * **<color #00a2e8>Official Name</color>**: Wnt ligand secretion mediator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79971|79971]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5T9L3|Q5T9L3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WLS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WLS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611514|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity). {ECO:0000250, ECO:0000269|PubMed:16678095, ECO:0000269|PubMed:16678096}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MIG-14 Wnt-bd|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Wnt protein secretion|
|positive regulation of Wnt protein secretion|
|mu-type opioid receptor binding|
|regulation of Wnt protein secretion|
|exocrine pancreas development|
|dendrite membrane|
|dendrite cytoplasm|
|Wnt-protein binding|
|exocrine system development|
|anterior/posterior axis specification|
|mesoderm formation|
|endocytic vesicle membrane|
|mesoderm morphogenesis|
|pancreas development|
|axis specification|
|midbrain development|
|formation of primary germ layer|
|mesoderm development|
|digestive system development|
|positive regulation of canonical Wnt signaling pathway|
|hindbrain development|
|early endosome membrane|
|protein secretion|
|gastrulation|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|signal release|
|trans-Golgi network|
|peptide secretion|
|positive regulation of Wnt signaling pathway|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|anterior/posterior pattern specification|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|cytoplasmic vesicle|
|early endosome|
|positive regulation of protein secretion|
|regulation of canonical Wnt signaling pathway|
|positive regulation of peptide secretion|
|regionalization|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|positive regulation of secretion by cell|
|gland development|
|positive regulation of protein transport|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|positive regulation of secretion|
|pattern specification process|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of peptide secretion|
|tissue morphogenesis|
|embryonic morphogenesis|
|Golgi membrane|
|regulation of protein transport|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|head development|
|regulation of secretion|
|anatomical structure formation involved in morphogenesis|
|endoplasmic reticulum membrane|
|embryo development|
|central nervous system development|
|Golgi apparatus|
|positive regulation of transport|
|intracellular protein transport|
|secretion by cell|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|export from cell|
|cell-cell signaling|
|secretion|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of signal transduction|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.83|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.72|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.88|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14754
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WLS Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>