WLS

Entrez Summary: N/A
UniProt Summary: Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity). {ECO:0000250, ECO:0000269|PubMed:16678095, ECO:0000269|PubMed:16678096}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Wnt protein secretion
positive regulation of Wnt protein secretion
mu-type opioid receptor binding
regulation of Wnt protein secretion
exocrine pancreas development
dendrite membrane
dendrite cytoplasm
Wnt-protein binding
exocrine system development
anterior/posterior axis specification
mesoderm formation
endocytic vesicle membrane
mesoderm morphogenesis
pancreas development
axis specification
midbrain development
formation of primary germ layer
mesoderm development
digestive system development
positive regulation of canonical Wnt signaling pathway
hindbrain development
early endosome membrane
protein secretion
gastrulation
establishment of protein localization to extracellular region
protein localization to extracellular region
signal release
trans-Golgi network
peptide secretion
positive regulation of Wnt signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
anterior/posterior pattern specification
regulation of I-kappaB kinase/NF-kappaB signaling
cytoplasmic vesicle
early endosome
positive regulation of protein secretion
regulation of canonical Wnt signaling pathway
positive regulation of peptide secretion
regionalization
Wnt signaling pathway