WNT2B [The Human Chemical-Genetic Interaction Map Project]

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======= WNT2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WNT2B
  * **<color #00a2e8>Official Name</color>**: Wnt family member 2B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7482|7482]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q93097|Q93097]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WNT2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WNT2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601968|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta- catenin signaling pathway. Plays a redundant role in embryonic lung development. {ECO:0000250|UniProtKB:O70283}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|wnt|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lung induction|
|positive regulation of branching involved in lung morphogenesis|
|regulation of branching involved in lung morphogenesis|
|mesenchymal-epithelial cell signaling|
|cornea development in camera-type eye|
|iris morphogenesis|
|hematopoietic stem cell proliferation|
|organ induction|
|positive regulation of branching involved in ureteric bud morphogenesis|
|positive regulation of mesonephros development|
|regulation of branching involved in ureteric bud morphogenesis|
|forebrain regionalization|
|regulation of mesonephros development|
|developmental induction|
|positive regulation of morphogenesis of an epithelium|
|regulation of animal organ formation|
|positive regulation of embryonic development|
|frizzled binding|
|positive regulation of kidney development|
|stem cell proliferation|
|regulation of kidney development|
|regulation of morphogenesis of a branching structure|
|lens development in camera-type eye|
|positive regulation of animal organ morphogenesis|
|chondrocyte differentiation|
|canonical Wnt signaling pathway|
|camera-type eye morphogenesis|
|regulation of embryonic development|
|male gonad development|
|development of primary male sexual characteristics|
|eye morphogenesis|
|cellular response to starvation|
|male sex differentiation|
|cartilage development|
|regulation of morphogenesis of an epithelium|
|response to starvation|
|gonad development|
|development of primary sexual characteristics|
|connective tissue development|
|cellular response to nutrient levels|
|cell fate commitment|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|cellular response to extracellular stimulus|
|sex differentiation|
|camera-type eye development|
|regionalization|
|cellular response to external stimulus|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|eye development|
|visual system development|
|collagen-containing extracellular matrix|
|sensory system development|
|forebrain development|
|reproductive structure development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|reproductive system development|
|pattern specification process|
|skeletal system development|
|response to nutrient levels|
|response to extracellular stimulus|
|sensory organ development|
|cell population proliferation|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|developmental process involved in reproduction|
|intracellular membrane-bounded organelle|
|brain development|
|head development|
|animal organ morphogenesis|
|central nervous system development|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|cell-cell signaling|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|generation of neurons|
|extracellular space|
|neurogenesis|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|tissue development|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.71|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.73|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.75|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.84|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5256
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WNT2B Expression in NALM6 Cells: 2.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>