WNT2B

Entrez Summary: This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].
UniProt Summary: Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta- catenin signaling pathway. Plays a redundant role in embryonic lung development. {ECO:0000250|UniProtKB:O70283}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Demecolcine 0.03μM R05 exp228	-1.71
THZ531 0.11 to 0.175μM on day4 R07 exp413	1.73
Dynasore 7μM R08 exp436	1.75
All-trans-Retinoic-Acid 40μM R07 exp334	1.84
∆-9-Tetrahydrocannabinol 30μM R08 exp445	1.89

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

lung induction
positive regulation of branching involved in lung morphogenesis
regulation of branching involved in lung morphogenesis
mesenchymal-epithelial cell signaling
cornea development in camera-type eye
iris morphogenesis
hematopoietic stem cell proliferation
organ induction
positive regulation of branching involved in ureteric bud morphogenesis
positive regulation of mesonephros development
regulation of branching involved in ureteric bud morphogenesis
forebrain regionalization
regulation of mesonephros development
developmental induction
positive regulation of morphogenesis of an epithelium
regulation of animal organ formation
positive regulation of embryonic development
frizzled binding
positive regulation of kidney development
stem cell proliferation
regulation of kidney development
regulation of morphogenesis of a branching structure
lens development in camera-type eye
positive regulation of animal organ morphogenesis
chondrocyte differentiation
canonical Wnt signaling pathway
camera-type eye morphogenesis
regulation of embryonic development
male gonad development
development of primary male sexual characteristics
eye morphogenesis
cellular response to starvation
male sex differentiation
cartilage development
regulation of morphogenesis of an epithelium
response to starvation
gonad development
development of primary sexual characteristics
connective tissue development
cellular response to nutrient levels