WNT3

Gene Information

Official Symbol: WNT3
Official Name: Wnt family member 3
Aliases and Previous Symbols: N/A
Entrez ID: 7473
UniProt: P56703
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008].
UniProt Summary: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (By similarity). Required for normal embryonic development, and especially for limb development (PubMed:14872406). {ECO:0000250|UniProtKB:P17553, ECO:0000269|PubMed:14872406, ECO:0000269|PubMed:26902720, ECO:0000305}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3844
Expression level (log2 read counts): 1.24

Expression Distribution

Screen	Score
Phenformin 20μM R03 exp143	1.7
6-Thio-2-deoxyguanosine 2μM R06 exp259	1.74
MK2206 4μM R08 exp504	1.75
Myriocin 25μM R06 exp293	1.77

Spemann organizer formation at the anterior end of the primitive streak
canonical Wnt signaling pathway involved in stem cell proliferation
positive regulation of collateral sprouting in absence of injury
canonical Wnt signaling pathway involved in osteoblast differentiation
canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
mesenchymal stem cell differentiation
regulation of collateral sprouting in absence of injury
canonical Wnt signaling pathway involved in regulation of cell proliferation
Spemann organizer formation
canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
positive regulation of collateral sprouting
limb bud formation
dorsal/ventral axis specification
Wnt signalosome
midbrain dopaminergic neuron differentiation
regulation of collateral sprouting
negative regulation of axon extension involved in axon guidance
developmental induction
embryonic hindlimb morphogenesis
negative regulation of axon guidance
dopaminergic neuron differentiation
regulation of axon extension involved in axon guidance
embryonic forelimb morphogenesis
receptor ligand activity
hindlimb morphogenesis
head morphogenesis
frizzled binding
forelimb morphogenesis
negative regulation of axon extension
regulation of axon guidance
body morphogenesis
anterior/posterior axis specification
stem cell proliferation
negative regulation of chemotaxis
mammary gland epithelium development
mesoderm formation
endocytic vesicle membrane
cellular response to retinoic acid
negative regulation of axonogenesis