WNT4

Gene Information

Official Symbol: WNT4
Official Name: Wnt family member 4
Aliases and Previous Symbols: N/A
Entrez ID: 54361
UniProt: P56705
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq, Jul 2008].
UniProt Summary: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4085
Expression level (log2 read counts): 0.28

Expression Distribution

Screen	Score
MK2206 4μM R08 exp504	-1.87
SGC2043 10μM R03 exp152	1.8
S-DABN 8μM R03 exp112	2.84

immature T cell proliferation
negative regulation of male gonad development
positive regulation of glucocorticoid biosynthetic process
positive regulation of glucocorticoid metabolic process
negative regulation of testicular blood vessel morphogenesis
positive regulation of cortisol biosynthetic process
negative regulation of androgen biosynthetic process
immature T cell proliferation in thymus
negative regulation of testosterone biosynthetic process
female sex determination
positive regulation of aldosterone metabolic process
positive regulation of aldosterone biosynthetic process
regulation of testosterone biosynthetic process
thyroid-stimulating hormone-secreting cell differentiation
tertiary branching involved in mammary gland duct morphogenesis
positive regulation of dermatome development
renal vesicle induction
positive regulation of steroid hormone biosynthetic process
regulation of dermatome development
paramesonephric duct development
somatotropin secreting cell differentiation
metanephric mesenchymal cell differentiation
regulation of cortisol biosynthetic process
mammary gland branching involved in pregnancy
negative regulation of gonad development
renal vesicle formation
non-canonical Wnt signaling pathway via MAPK cascade
metanephric tubule formation
regulation of aldosterone biosynthetic process
regulation of aldosterone metabolic process
regulation of glucocorticoid biosynthetic process
neuroendocrine cell differentiation
mesenchymal cell differentiation involved in renal system development
mesenchymal cell differentiation involved in kidney development
regulation of glucocorticoid metabolic process
regulation of male gonad development
negative regulation of hormone biosynthetic process
regulation of steroid hormone biosynthetic process
positive regulation of hormone biosynthetic process
metanephric tubule morphogenesis