WNT7A

Gene Information

Official Symbol: WNT7A
Official Name: Wnt family member 7A
Aliases and Previous Symbols: N/A
Entrez ID: 7476
UniProt: O00755
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. [provided by RefSeq, Jul 2008].
UniProt Summary: Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PubMed:16826533). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal neural stem cell proliferation in the hippocampus dentate gyrus. Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation. Promotes formation of synapses via its interaction with FZD5 (By similarity). {ECO:0000250|UniProtKB:P24383, ECO:0000269|PubMed:16826533}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7819
Expression level (log2 read counts): -1.65

Expression Distribution

asymmetric protein localization involved in cell fate determination
positive regulation of protein localization to presynapse
regulation of protein localization to presynapse
oviduct development
positive regulation of excitatory synapse assembly
central nervous system vasculogenesis
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
establishment of endothelial blood-brain barrier
skeletal muscle satellite cell activation
regulation of axon diameter
uterus morphogenesis
cerebellar granule cell differentiation
cerebellar granular layer formation
establishment of blood-brain barrier
positive regulation of epithelial cell proliferation involved in wound healing
cerebellar granular layer morphogenesis
wound healing, spreading of epidermal cells
positive regulation of protein localization to synapse
cerebellar granular layer development
regulation of cell projection size
lens fiber cell development
regulation of excitatory synapse assembly
excitatory synapse assembly
dendritic spine morphogenesis
postsynapse assembly
cell differentiation in hindbrain
presynapse assembly
cartilage condensation
cerebellar cortex formation
cell aggregation
uterus development
presynapse organization
somatic stem cell division
secondary palate development
epiboly involved in wound healing
wound healing, spreading of cells
epiboly
regulation of protein localization to synapse
lens fiber cell differentiation
embryonic hindlimb morphogenesis