WRN [The Human Chemical-Genetic Interaction Map Project]

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======= WRN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WRN
  * **<color #00a2e8>Official Name</color>**: WRN RecQ like helicase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7486|7486]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14191|Q14191]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WRN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WRN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604611|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Multifunctional enzyme that has both magnesium and ATP- dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double- stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation. {ECO:0000250, ECO:0000269|PubMed:11863428, ECO:0000269|PubMed:17563354, ECO:0000269|PubMed:18596042, ECO:0000269|PubMed:19283071, ECO:0000269|PubMed:19652551, ECO:0000269|PubMed:21639834}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DEAD|
|RQC|
|DNA pol A exo1|
|HRDC|
|Helicase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|3-flap-structured DNA binding|
|regulation of strand invasion|
|positive regulation of strand invasion|
|forked DNA-dependent helicase activity|
|telomeric G-quadruplex DNA binding|
|8-hydroxy-2-deoxyguanosine DNA binding|
|telomeric D-loop binding|
|four-way junction helicase activity|
|replicative cell aging|
|Y-form DNA binding|
|G-quadruplex DNA unwinding|
|protein localization to nucleolus|
|MutLalpha complex binding|
|regulation of growth rate|
|bubble DNA binding|
|telomeric D-loop disassembly|
|G-quadruplex DNA binding|
|t-circle formation|
|telomere maintenance via telomere trimming|
|formation of extrachromosomal circular DNA|
|telomeric loop disassembly|
|DNA unwinding involved in DNA replication|
|exonuclease activity|
|response to UV-C|
|four-way junction DNA binding|
|3-5 DNA helicase activity|
|3-5 exonuclease activity|
|replication fork|
|cellular response to gamma radiation|
|replication fork processing|
|helicase activity|
|multicellular organism aging|
|base-excision repair|
|positive regulation of DNA recombination|
|DNA-dependent DNA replication maintenance of fidelity|
|chromosome, telomeric region|
|DNA synthesis involved in DNA repair|
|response to gamma radiation|
|DNA helicase activity|
|manganese ion binding|
|cell aging|
|cellular response to ionizing radiation|
|double-strand break repair via homologous recombination|
|recombinational repair|
|telomere maintenance|
|telomere organization|
|regulation of DNA recombination|
|DNA biosynthetic process|
|DNA duplex unwinding|
|DNA geometric change|
|DNA-dependent DNA replication|
|chromosome|
|response to UV|
|response to ionizing radiation|
|cellular response to starvation|
|protein localization to nucleus|
|cellular response to radiation|
|regulation of signal transduction by p53 class mediator|
|double-strand break repair|
|positive regulation of DNA metabolic process|
|response to starvation|
|DNA replication|
|magnesium ion binding|
|DNA recombination|
|cellular response to nutrient levels|
|ATPase activity|
|cellular response to extracellular stimulus|
|protein-containing complex binding|
|aging|
|DNA conformation change|
|nucleic acid phosphodiester bond hydrolysis|
|response to light stimulus|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|neuron projection|
|cellular response to external stimulus|
|anatomical structure homeostasis|
|regulation of DNA metabolic process|
|response to oxidative stress|
|chromatin binding|
|nuclear speck|
|response to radiation|
|centrosome|
|response to nutrient levels|
|DNA repair|
|response to extracellular stimulus|
|regulation of growth|
|protein localization to organelle|
|brain development|
|DNA metabolic process|
|positive regulation of hydrolase activity|
|cellular response to DNA damage stimulus|
|head development|
|nucleolus|
|protein homodimerization activity|
|central nervous system development|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of hydrolase activity|
|organic cyclic compound biosynthetic process|
|positive regulation of catalytic activity|
|DNA binding|
|ATP binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|regulation of cell death|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 9/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9848
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WRN Expression in NALM6 Cells: 5.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>