WTAP [The Human Chemical-Genetic Interaction Map Project]

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======= WTAP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WTAP
  * **<color #00a2e8>Official Name</color>**: WT1 associated protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9589|9589]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15007|Q15007]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WTAP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WTAP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605442|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724). {ECO:0000269|PubMed:12444081, ECO:0000269|PubMed:17088532, ECO:0000269|PubMed:17095724, ECO:0000269|PubMed:24316715, ECO:0000269|PubMed:24407421, ECO:0000269|PubMed:24981863}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA N6-methyladenosine methyltransferase complex|
|mRNA methylation|
|mRNA modification|
|regulation of alternative mRNA splicing, via spliceosome|
|RNA methylation|
|regulation of mRNA splicing, via spliceosome|
|regulation of RNA splicing|
|regulation of mRNA processing|
|RNA modification|
|nuclear membrane|
|macromolecule methylation|
|methylation|
|regulation of mRNA metabolic process|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|cell cycle|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.13|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-2.05|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-2.01|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-1.89|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.88|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.88|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-1.87|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.74|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.71|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-1.7|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.71|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.75|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|1.76|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.78|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.83|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|1.86|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|1.95|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|2|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.04|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|2.24|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.32|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.68|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 67/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|2/28|
|bone|0/26|
|breast|5/33|
|central nervous system|1/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|0/21|
|liver|0/20|
|lung|6/75|
|lymphocyte|1/16|
|ovary|4/26|
|pancreas|2/24|
|peripheral nervous system|1/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|5/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2264
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WTAP Expression in NALM6 Cells: 7.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>