WTAP

Entrez Summary: N/A
UniProt Summary: Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724). {ECO:0000269|PubMed:12444081, ECO:0000269|PubMed:17088532, ECO:0000269|PubMed:17095724, ECO:0000269|PubMed:24316715, ECO:0000269|PubMed:24407421, ECO:0000269|PubMed:24981863}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UM0125461 0.74μM R02 exp84	-2.13
FK-506 30μM R07 exp359	-2.05
Deferoxamine 11μM R07 exp350	-2.01
CCT251545 20μM R07 exp326	-1.89
Diepoxybutane 3μM R07 exp354	-1.88
Monensin 0.3μM R08 exp507	-1.88
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-1.87
Hydroxyurea 100μM R07 exp329	-1.74
I-BRD9 4μM R07 exp365	-1.71
Tozasertib 0.1μM R07 exp414	-1.7
Citral 50μM R06 exp274	1.71
Wortmannin 0.5μM R00 exp37	1.75
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	1.76
UM0131023 0.05μM R05 exp248	1.78
Torin1 0.08μM R02 exp82	1.83
L-BMAA 500 to 750μM on day4 R04 exp185	1.86
YM155 0.001μM R08 exp432	1.95
Radicicol 0.16μM R05 exp242	2
AICAR 240μM R03 exp116	2.04
UM0011500 10μM R05 exp246	2.24
CCCP 1μM R00 exp11	2.32
Artemisinin 50μM R08 exp450	2.68

Global Fraction of Cell Lines Where Essential: 67/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	4/28
blood	2/28
bone	0/26
breast	5/33
central nervous system	1/56
cervix	1/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	4/16
kidney	0/21
liver	0/20
lung	6/75
lymphocyte	1/16
ovary	4/26
pancreas	2/24
peripheral nervous system	1/16
plasma cell	4/15
prostate	0/1
skin	2/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	5/29
uterus	1/5

Expression Distribution

RNA N6-methyladenosine methyltransferase complex
mRNA methylation
mRNA modification
regulation of alternative mRNA splicing, via spliceosome
RNA methylation
regulation of mRNA splicing, via spliceosome
regulation of RNA splicing
regulation of mRNA processing
RNA modification
nuclear membrane
macromolecule methylation
methylation
regulation of mRNA metabolic process
RNA splicing
nuclear speck
mRNA processing
mRNA metabolic process
RNA processing
cell cycle
RNA metabolic process
gene expression