WWP2
Gene Information
- Official Symbol: WWP2
- Official Name: WW domain containing E3 ubiquitin protein ligase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 11060
- UniProt: O00308
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| WW |
| HECT |
GO Terms
| extracellular transport |
| protein K63-linked ubiquitination |
| negative regulation of Notch signaling pathway |
| regulation of potassium ion transmembrane transporter activity |
| RNA polymerase II transcription factor binding |
| protein autoubiquitination |
| negative regulation of transporter activity |
| regulation of potassium ion transmembrane transport |
| viral entry into host cell |
| regulation of potassium ion transport |
| entry into host cell |
| regulation of Notch signaling pathway |
| entry into host |
| ubiquitin ligase complex |
| interaction with host |
| negative regulation of DNA-binding transcription factor activity |
| negative regulation of protein transport |
| negative regulation of establishment of protein localization |
| viral life cycle |
| positive regulation of protein catabolic process |
| ubiquitin protein ligase activity |
| ubiquitin-protein transferase activity |
| regulation of ion transmembrane transporter activity |
| regulation of transmembrane transporter activity |
| regulation of transporter activity |
| protein polyubiquitination |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| transcription factor binding |
| regulation of cation transmembrane transport |
| proteasomal protein catabolic process |
| regulation of protein catabolic process |
| regulation of metal ion transport |
| regulation of DNA-binding transcription factor activity |
| regulation of membrane potential |
| positive regulation of catabolic process |
| regulation of ion transmembrane transport |
| negative regulation of transport |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| regulation of transmembrane transport |
| proteolysis involved in cellular protein catabolic process |
| cellular protein catabolic process |
| protein catabolic process |
| protein ubiquitination |
| regulation of ion transport |
| viral process |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| protein modification by small protein conjugation |
| symbiotic process |
| interspecies interaction between organisms |
| negative regulation of transcription by RNA polymerase II |
| cellular macromolecule catabolic process |
| protein modification by small protein conjugation or removal |
| regulation of catabolic process |
| regulation of protein localization |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| negative regulation of molecular function |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| proteolysis |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| organic substance catabolic process |
| cellular catabolic process |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18250
- Expression level (log2 read counts): 5.81
Expression Distribution
WWP2 Expression in NALM6 Cells: 5.81
