XCL1
Gene Information
- Official Symbol: XCL1
- Official Name: X-C motif chemokine ligand 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 6375
- UniProt: P47992
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment. {ECO:0000250|UniProtKB:P47993}.
Pfam Domains GO Terms
Pfam Domains
| IL8 |
GO Terms
| positive regulation of granzyme A production |
| negative regulation of T-helper 1 cell activation |
| regulation of T-helper 1 cell activation |
| regulation of granzyme A production |
| mature natural killer cell chemotaxis |
| positive regulation of CD8-positive, alpha-beta T cell proliferation |
| regulation of immunoglobulin production in mucosal tissue |
| positive regulation of B cell chemotaxis |
| regulation of granzyme B production |
| positive regulation of immunoglobulin production in mucosal tissue |
| positive regulation of granzyme B production |
| regulation of B cell chemotaxis |
| natural killer cell chemotaxis |
| positive regulation of thymocyte migration |
| regulation of thymocyte migration |
| regulation of T-helper 1 cell cytokine production |
| positive regulation of CD4-positive, alpha-beta T cell proliferation |
| positive regulation of T-helper 1 cell cytokine production |
| positive regulation of natural killer cell chemotaxis |
| regulation of CD8-positive, alpha-beta T cell proliferation |
| positive regulation of CD8-positive, alpha-beta T cell activation |
| negative regulation of T-helper 1 type immune response |
| positive regulation of T-helper 2 cell cytokine production |
| chemokine receptor binding |
| negative regulation of CD4-positive, alpha-beta T cell proliferation |
| regulation of natural killer cell chemotaxis |
| negative regulation of T cell cytokine production |
| negative regulation of alpha-beta T cell proliferation |
| regulation of CD4-positive, alpha-beta T cell proliferation |
| regulation of T-helper 2 cell cytokine production |
| regulation of CD8-positive, alpha-beta T cell activation |
| positive regulation of type 2 immune response |
| positive regulation of T cell chemotaxis |
| regulation of T cell chemotaxis |
| negative regulation of T cell mediated immunity |
| positive regulation of alpha-beta T cell proliferation |
| positive regulation of T cell cytokine production |
| positive regulation of transforming growth factor beta production |
| positive regulation of T-helper 1 type immune response |
| positive regulation of lymphocyte chemotaxis |
| negative regulation of interleukin-2 production |
| positive regulation of neutrophil chemotaxis |
| negative regulation of cytokine production involved in immune response |
| regulation of lymphocyte chemotaxis |
| positive regulation of granulocyte chemotaxis |
| positive regulation of T cell mediated cytotoxicity |
| regulation of T-helper 1 type immune response |
| cellular response to interleukin-4 |
| CCR chemokine receptor binding |
| negative regulation of CD4-positive, alpha-beta T cell activation |
| regulation of neutrophil chemotaxis |
| positive regulation of neutrophil migration |
| regulation of type 2 immune response |
| regulation of alpha-beta T cell proliferation |
| response to interleukin-4 |
| regulation of T cell cytokine production |
| positive regulation of T cell migration |
| regulation of T cell mediated cytotoxicity |
| negative regulation of interferon-gamma production |
| positive regulation of CD4-positive, alpha-beta T cell activation |
| negative regulation of production of molecular mediator of immune response |
| regulation of transforming growth factor beta production |
| positive regulation of interleukin-10 production |
| regulation of neutrophil migration |
| positive regulation of immunoglobulin mediated immune response |
| positive regulation of B cell mediated immunity |
| positive regulation of lymphocyte migration |
| negative regulation of lymphocyte mediated immunity |
| negative regulation of alpha-beta T cell activation |
| negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| positive regulation of release of sequestered calcium ion into cytosol |
| monocyte chemotaxis |
| positive regulation of immunoglobulin production |
| regulation of granulocyte chemotaxis |
| regulation of T cell migration |
| negative regulation of adaptive immune response |
| lymphocyte chemotaxis |
| positive regulation of T cell mediated immunity |
| mononuclear cell migration |
| negative regulation of leukocyte mediated immunity |
| chemokine activity |
| regulation of B cell mediated immunity |
| regulation of immunoglobulin mediated immune response |
| regulation of interleukin-10 production |
| positive regulation of cytokine production involved in immune response |
| positive regulation of calcium ion transport into cytosol |
| regulation of interleukin-2 production |
| release of sequestered calcium ion into cytosol |
| positive regulation of leukocyte mediated cytotoxicity |
| negative regulation of sequestering of calcium ion |
| regulation of CD4-positive, alpha-beta T cell activation |
| positive regulation of alpha-beta T cell activation |
| negative regulation of T cell proliferation |
| regulation of lymphocyte migration |
| regulation of immunoglobulin production |
| calcium ion transmembrane import into cytosol |
| lymphocyte migration |
| positive regulation of cell killing |
| positive regulation of calcium ion transmembrane transport |
| regulation of T cell mediated immunity |
| calcium ion transport into cytosol |
| negative regulation of mononuclear cell proliferation |
| negative regulation of lymphocyte proliferation |
| regulation of leukocyte mediated cytotoxicity |
| regulation of release of sequestered calcium ion into cytosol |
| negative regulation of leukocyte proliferation |
| chemokine-mediated signaling pathway |
| cell |
| neutrophil chemotaxis |
| regulation of cytokine production involved in immune response |
| positive regulation of leukocyte chemotaxis |
| cytosolic calcium ion transport |
| granulocyte chemotaxis |
| cellular response to chemokine |
| response to chemokine |
| neutrophil migration |
| regulation of alpha-beta T cell activation |
| positive regulation of T cell proliferation |
| positive regulation of production of molecular mediator of immune response |
| regulation of interferon-gamma production |
| regulation of calcium ion transport into cytosol |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| granulocyte migration |
| regulation of cell killing |
| positive regulation of adaptive immune response |
| positive regulation of lymphocyte mediated immunity |
| negative regulation of T cell activation |
| regulation of leukocyte chemotaxis |
| negative regulation of immune effector process |
| positive regulation of calcium ion transport |
| negative regulation of leukocyte cell-cell adhesion |
| regulation of sequestering of calcium ion |
| myeloid leukocyte migration |
| positive regulation of leukocyte migration |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| positive regulation of leukocyte mediated immunity |
| positive regulation of chemotaxis |
| positive regulation of leukocyte proliferation |
| regulation of production of molecular mediator of immune response |
| positive regulation of cation transmembrane transport |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| leukocyte chemotaxis |
| negative regulation of lymphocyte activation |
| regulation of calcium ion transmembrane transport |
| negative regulation of immune response |
| regulation of lymphocyte mediated immunity |
| positive regulation of ion transmembrane transport |
| cellular response to transforming growth factor beta stimulus |
| regulation of T cell proliferation |
| regulation of adaptive immune response |
| negative regulation of DNA-binding transcription factor activity |
| cellular response to interferon-gamma |
| response to transforming growth factor beta |
| negative regulation of leukocyte activation |
| cellular response to interleukin-1 |
| negative regulation of cell-cell adhesion |
| response to interferon-gamma |
| regulation of leukocyte migration |
| negative regulation of cell activation |
| calcium ion transmembrane transport |
| response to interleukin-1 |
| positive regulation of transmembrane transport |
| positive regulation of T cell activation |
| regulation of leukocyte mediated immunity |
| regulation of lymphocyte proliferation |
| cell chemotaxis |
| regulation of mononuclear cell proliferation |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of chemotaxis |
| positive regulation of leukocyte cell-cell adhesion |
| positive regulation of immune effector process |
| regulation of leukocyte proliferation |
| cellular response to tumor necrosis factor |
| regulation of calcium ion transport |
| calcium ion transport |
| positive regulation of cell-cell adhesion |
| response to tumor necrosis factor |
| negative regulation of cell adhesion |
| negative regulation of cytokine production |
| positive regulation of ion transport |
| response to virus |
| positive regulation of cytosolic calcium ion concentration |
| regulation of ERK1 and ERK2 cascade |
| divalent metal ion transport |
| regulation of leukocyte cell-cell adhesion |
| divalent inorganic cation transport |
| regulation of T cell activation |
| regulation of cytosolic calcium ion concentration |
| regulation of cation transmembrane transport |
| regulation of inflammatory response |
| positive regulation of lymphocyte activation |
| leukocyte migration |
| regulation of metal ion transport |
| regulation of cell-cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of cell adhesion |
| positive regulation of GTPase activity |
| positive regulation of cell activation |
| regulation of DNA-binding transcription factor activity |
| cellular calcium ion homeostasis |
| negative regulation of immune system process |
| positive regulation of cytokine production |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| regulation of immune effector process |
| regulation of ion transmembrane transport |
| regulation of GTPase activity |
| divalent inorganic cation homeostasis |
| inflammatory response |
| positive regulation of cell migration |
| cellular response to growth factor stimulus |
| regulation of lymphocyte activation |
| positive regulation of cell motility |
| response to growth factor |
| positive regulation of cellular component movement |
| positive regulation of MAPK cascade |
| chemotaxis |
| taxis |
| positive regulation of locomotion |
| cellular metal ion homeostasis |
| inorganic cation transmembrane transport |
| regulation of transmembrane transport |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| cation transmembrane transport |
| metal ion homeostasis |
| cellular cation homeostasis |
| metal ion transport |
| regulation of cell activation |
| cellular ion homeostasis |
| inorganic ion transmembrane transport |
| cytokine-mediated signaling pathway |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| regulation of cytokine production |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| regulation of MAPK cascade |
| regulation of defense response |
| innate immune response |
| positive regulation of hydrolase activity |
| ion homeostasis |
| cation transport |
| regulation of cell migration |
| positive regulation of immune response |
| protein homodimerization activity |
| cellular homeostasis |
| regulation of cell motility |
| regulation of cellular localization |
| positive regulation of cell population proliferation |
| ion transmembrane transport |
| defense response to other organism |
| cell migration |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| localization of cell |
| cell motility |
| regulation of response to external stimulus |
| response to cytokine |
| chemical homeostasis |
| cell-cell signaling |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| regulation of immune response |
| positive regulation of immune system process |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| transmembrane transport |
| regulation of hydrolase activity |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| G protein-coupled receptor signaling pathway |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| defense response |
| ion transport |
| negative regulation of cellular macromolecule biosynthetic process |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of immune system process |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12420
- Expression level (log2 read counts): -6.6
Expression Distribution
XCL1 Expression in NALM6 Cells: -6.6
