XK [The Human Chemical-Genetic Interaction Map Project]

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======= XK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: XK
  * **<color #00a2e8>Official Name</color>**: X-linked Kx blood group
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7504|7504]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51811|P51811]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=XK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20XK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/314850|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This locus controls the synthesis of the Kell blood group 'precursor substance' (Kx). Mutations in this gene have been associated with McLeod syndrome, an X-linked, recessive disorder characterized by abnormalities in the neuromuscular and hematopoietic systems. The encoded protein has structural characteristics of prokaryotic and eukaryotic membrane transport proteins. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in sodium-dependent transport of neutral amino acids or oligopeptides.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|XK-related|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of axon diameter|
|cellular magnesium ion homeostasis|
|magnesium ion homeostasis|
|regulation of cell projection size|
|skeletal muscle fiber development|
|myotube cell development|
|transporter activity|
|myotube differentiation|
|muscle fiber development|
|myelination|
|axon ensheathment|
|ensheathment of neurons|
|amino acid transport|
|skeletal muscle tissue development|
|skeletal muscle organ development|
|striated muscle cell development|
|muscle cell development|
|regulation of cell size|
|regulation of axonogenesis|
|striated muscle cell differentiation|
|muscle cell differentiation|
|striated muscle tissue development|
|organic acid transport|
|carboxylic acid transport|
|muscle organ development|
|muscle tissue development|
|regulation of cell morphogenesis involved in differentiation|
|regulation of cellular component size|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|organic anion transport|
|cellular divalent inorganic cation homeostasis|
|muscle structure development|
|regulation of cell morphogenesis|
|divalent inorganic cation homeostasis|
|regulation of neuron projection development|
|regulation of anatomical structure size|
|cellular metal ion homeostasis|
|anion transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|cation homeostasis|
|regulation of cell projection organization|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|regulation of neurogenesis|
|cellular homeostasis|
|regulation of nervous system development|
|regulation of cell development|
|regulation of anatomical structure morphogenesis|
|chemical homeostasis|
|ion transport|
|generation of neurons|
|neurogenesis|
|homeostatic process|
|cell development|
|tissue development|
|regulation of cell differentiation|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16772
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='XK Expression in NALM6 Cells: -2.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>