XYLT1

Entrez Summary: This locus encodes a xylosyltransferase enzyme. The encoded protein catalyzes transfer of UDP-xylose to serine residues of an acceptor protein substrate. This transfer reaction is necessary for biosynthesis of glycosaminoglycan chains. Mutations in this gene have been associated with increased severity of pseudoxanthoma elasticum.[provided by RefSeq, Nov 2009].
UniProt Summary: Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes. {ECO:0000269|PubMed:15461586}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Branch
Xylo C

protein xylosyltransferase activity
ossification involved in bone maturation
bone maturation
animal organ maturation
acetylglucosaminyltransferase activity
chondroitin sulfate biosynthetic process
Golgi cis cisterna
heparan sulfate proteoglycan biosynthetic process
chondroitin sulfate proteoglycan biosynthetic process
heparan sulfate proteoglycan metabolic process
chondroitin sulfate metabolic process
chondroitin sulfate proteoglycan metabolic process
proteoglycan biosynthetic process
proteoglycan metabolic process
glycosaminoglycan biosynthetic process
mucopolysaccharide metabolic process
aminoglycan biosynthetic process
embryonic skeletal system development
anatomical structure maturation
glycosaminoglycan metabolic process
aminoglycan metabolic process
sulfur compound biosynthetic process
bone development
developmental maturation
ossification
glycoprotein biosynthetic process
sulfur compound metabolic process
glycoprotein metabolic process
skeletal system development
Golgi membrane
carbohydrate derivative biosynthetic process
chordate embryonic development
embryo development ending in birth or egg hatching
embryo development
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
organonitrogen compound biosynthetic process
extracellular space
cellular macromolecule biosynthetic process