YAP1 [The Human Chemical-Genetic Interaction Map Project]

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======= YAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: YAP1
  * **<color #00a2e8>Official Name</color>**: Yes1 associated transcriptional regulator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10413|10413]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P46937|P46937]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=YAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20YAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606608|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WW|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TEAD-1-YAP complex|
|TEAD-2-YAP complex|
|cardiac muscle tissue regeneration|
|regulation of metanephric nephron tubule epithelial cell differentiation|
|bud elongation involved in lung branching|
|progesterone receptor signaling pathway|
|contact inhibition|
|positive regulation of stem cell population maintenance|
|positive regulation of intracellular estrogen receptor signaling pathway|
|lateral mesoderm development|
|regulation of nephron tubule epithelial cell differentiation|
|positive regulation of intracellular steroid hormone receptor signaling pathway|
|branch elongation of an epithelium|
|proline-rich region binding|
|paraxial mesoderm development|
|regulation of epithelial cell differentiation involved in kidney development|
|lung epithelial cell differentiation|
|notochord development|
|negative regulation of stem cell differentiation|
|lung cell differentiation|
|regulation of metanephros development|
|positive regulation of cardiac muscle cell proliferation|
|epithelial tube branching involved in lung morphogenesis|
|axis elongation|
|hippo signaling|
|regulation of stem cell population maintenance|
|lung epithelium development|
|cellular response to gamma radiation|
|activating transcription factor binding|
|positive regulation of cardiac muscle tissue growth|
|regulation of keratinocyte proliferation|
|positive regulation of heart growth|
|regulation of cardiac muscle cell proliferation|
|regulation of intracellular estrogen receptor signaling pathway|
|negative regulation of epithelial cell differentiation|
|lung morphogenesis|
|positive regulation of cardiac muscle tissue development|
|response to progesterone|
|positive regulation of organ growth|
|regulation of kidney development|
|response to gamma radiation|
|regulation of cardiac muscle tissue growth|
|tissue regeneration|
|regulation of heart growth|
|regulation of stem cell proliferation|
|somatic stem cell population maintenance|
|embryonic heart tube morphogenesis|
|vasculogenesis|
|intracellular steroid hormone receptor signaling pathway|
|cellular response to ionizing radiation|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle organ development|
|cellular response to retinoic acid|
|positive regulation of muscle tissue development|
|regulation of hematopoietic stem cell differentiation|
|embryonic heart tube development|
|regulation of intracellular steroid hormone receptor signaling pathway|
|regulation of cardiac muscle tissue development|
|regulation of hematopoietic progenitor cell differentiation|
|regulation of organ growth|
|heart process|
|negative regulation of extrinsic apoptotic signaling pathway|
|response to retinoic acid|
|developmental growth involved in morphogenesis|
|regulation of stem cell differentiation|
|steroid hormone mediated signaling pathway|
|mesoderm development|
|branching morphogenesis of an epithelial tube|
|regulation of striated muscle tissue development|
|stem cell population maintenance|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|maintenance of cell number|
|regulation of epithelial cell differentiation|
|positive regulation of canonical Wnt signaling pathway|
|response to ionizing radiation|
|regulation of extrinsic apoptotic signaling pathway|
|regeneration|
|morphogenesis of a branching epithelium|
|intracellular receptor signaling pathway|
|morphogenesis of a branching structure|
|lung development|
|hormone-mediated signaling pathway|
|positive regulation of developmental growth|
|respiratory tube development|
|cellular response to radiation|
|transcription initiation from RNA polymerase II promoter|
|positive regulation of Wnt signaling pathway|
|cellular response to steroid hormone stimulus|
|protein C-terminus binding|
|tissue homeostasis|
|response to ketone|
|respiratory system development|
|cellular response to acid chemical|
|DNA-templated transcription, initiation|
|transcription regulatory region DNA binding|
|mesenchyme development|
|negative regulation of apoptotic signaling pathway|
|transcription corepressor activity|
|heart morphogenesis|
|positive regulation of growth|
|keratinocyte differentiation|
|regulation of canonical Wnt signaling pathway|
|transcription coactivator activity|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|epidermal cell differentiation|
|multicellular organismal homeostasis|
|response to steroid hormone|
|regulation of developmental growth|
|regulation of epithelial cell proliferation|
|anatomical structure homeostasis|
|response to acid chemical|
|regulation of Wnt signaling pathway|
|skin development|
|developmental growth|
|growth|
|chromatin binding|
|circulatory system process|
|regulation of apoptotic signaling pathway|
|blood vessel morphogenesis|
|epidermis development|
|morphogenesis of an epithelium|
|embryonic organ development|
|response to radiation|
|regulation of hemopoiesis|
|wound healing|
|transcription by RNA polymerase II|
|blood vessel development|
|protein heterodimerization activity|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|vasculature development|
|cardiovascular system development|
|cellular response to lipid|
|heart development|
|cellular response to organic cyclic compound|
|cell population proliferation|
|tissue morphogenesis|
|embryonic morphogenesis|
|response to wounding|
|cellular response to hormone stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|tube morphogenesis|
|regulation of growth|
|epithelial cell differentiation|
|negative regulation of cell differentiation|
|cell morphogenesis|
|cellular response to DNA damage stimulus|
|regulation of neurogenesis|
|cellular component morphogenesis|
|tube development|
|response to lipid|
|circulatory system development|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|embryo development|
|negative regulation of cell death|
|response to drug|
|cellular response to oxygen-containing compound|
|nucleobase-containing compound biosynthetic process|
|epithelium development|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|RNA metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.02|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.97|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|-1.95|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 18/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|2/20|
|lung|3/75|
|lymphocyte|0/14|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7208
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='YAP1 Expression in NALM6 Cells: -2.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>