YAP1
Gene Information
- Official Symbol: YAP1
- Official Name: Yes1 associated transcriptional regulator
- Aliases and Previous Symbols: N/A
- Entrez ID: 10413
- UniProt: P46937
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| WW |
GO Terms
| TEAD-1-YAP complex |
| TEAD-2-YAP complex |
| cardiac muscle tissue regeneration |
| regulation of metanephric nephron tubule epithelial cell differentiation |
| bud elongation involved in lung branching |
| progesterone receptor signaling pathway |
| contact inhibition |
| positive regulation of stem cell population maintenance |
| positive regulation of intracellular estrogen receptor signaling pathway |
| lateral mesoderm development |
| regulation of nephron tubule epithelial cell differentiation |
| positive regulation of intracellular steroid hormone receptor signaling pathway |
| branch elongation of an epithelium |
| proline-rich region binding |
| paraxial mesoderm development |
| regulation of epithelial cell differentiation involved in kidney development |
| lung epithelial cell differentiation |
| notochord development |
| negative regulation of stem cell differentiation |
| lung cell differentiation |
| regulation of metanephros development |
| positive regulation of cardiac muscle cell proliferation |
| epithelial tube branching involved in lung morphogenesis |
| axis elongation |
| hippo signaling |
| regulation of stem cell population maintenance |
| lung epithelium development |
| cellular response to gamma radiation |
| activating transcription factor binding |
| positive regulation of cardiac muscle tissue growth |
| regulation of keratinocyte proliferation |
| positive regulation of heart growth |
| regulation of cardiac muscle cell proliferation |
| regulation of intracellular estrogen receptor signaling pathway |
| negative regulation of epithelial cell differentiation |
| lung morphogenesis |
| positive regulation of cardiac muscle tissue development |
| response to progesterone |
| positive regulation of organ growth |
| regulation of kidney development |
| response to gamma radiation |
| regulation of cardiac muscle tissue growth |
| tissue regeneration |
| regulation of heart growth |
| regulation of stem cell proliferation |
| somatic stem cell population maintenance |
| embryonic heart tube morphogenesis |
| vasculogenesis |
| intracellular steroid hormone receptor signaling pathway |
| cellular response to ionizing radiation |
| positive regulation of striated muscle tissue development |
| positive regulation of muscle organ development |
| cellular response to retinoic acid |
| positive regulation of muscle tissue development |
| regulation of hematopoietic stem cell differentiation |
| embryonic heart tube development |
| regulation of intracellular steroid hormone receptor signaling pathway |
| regulation of cardiac muscle tissue development |
| regulation of hematopoietic progenitor cell differentiation |
| regulation of organ growth |
| heart process |
| negative regulation of extrinsic apoptotic signaling pathway |
| response to retinoic acid |
| developmental growth involved in morphogenesis |
| regulation of stem cell differentiation |
| steroid hormone mediated signaling pathway |
| mesoderm development |
| branching morphogenesis of an epithelial tube |
| regulation of striated muscle tissue development |
| stem cell population maintenance |
| regulation of muscle tissue development |
| regulation of muscle organ development |
| maintenance of cell number |
| regulation of epithelial cell differentiation |
| positive regulation of canonical Wnt signaling pathway |
| response to ionizing radiation |
| regulation of extrinsic apoptotic signaling pathway |
| regeneration |
| morphogenesis of a branching epithelium |
| intracellular receptor signaling pathway |
| morphogenesis of a branching structure |
| lung development |
| hormone-mediated signaling pathway |
| positive regulation of developmental growth |
| respiratory tube development |
| cellular response to radiation |
| transcription initiation from RNA polymerase II promoter |
| positive regulation of Wnt signaling pathway |
| cellular response to steroid hormone stimulus |
| protein C-terminus binding |
| tissue homeostasis |
| response to ketone |
| respiratory system development |
| cellular response to acid chemical |
| DNA-templated transcription, initiation |
| transcription regulatory region DNA binding |
| mesenchyme development |
| negative regulation of apoptotic signaling pathway |
| transcription corepressor activity |
| heart morphogenesis |
| positive regulation of growth |
| keratinocyte differentiation |
| regulation of canonical Wnt signaling pathway |
| transcription coactivator activity |
| embryonic organ morphogenesis |
| epithelial tube morphogenesis |
| cellular response to abiotic stimulus |
| cellular response to environmental stimulus |
| epidermal cell differentiation |
| multicellular organismal homeostasis |
| response to steroid hormone |
| regulation of developmental growth |
| regulation of epithelial cell proliferation |
| anatomical structure homeostasis |
| response to acid chemical |
| regulation of Wnt signaling pathway |
| skin development |
| developmental growth |
| growth |
| chromatin binding |
| circulatory system process |
| regulation of apoptotic signaling pathway |
| blood vessel morphogenesis |
| epidermis development |
| morphogenesis of an epithelium |
| embryonic organ development |
| response to radiation |
| regulation of hemopoiesis |
| wound healing |
| transcription by RNA polymerase II |
| blood vessel development |
| protein heterodimerization activity |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| vasculature development |
| cardiovascular system development |
| cellular response to lipid |
| heart development |
| cellular response to organic cyclic compound |
| cell population proliferation |
| tissue morphogenesis |
| embryonic morphogenesis |
| response to wounding |
| cellular response to hormone stimulus |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| tube morphogenesis |
| regulation of growth |
| epithelial cell differentiation |
| negative regulation of cell differentiation |
| cell morphogenesis |
| cellular response to DNA damage stimulus |
| regulation of neurogenesis |
| cellular component morphogenesis |
| tube development |
| response to lipid |
| circulatory system development |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| response to hormone |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| animal organ morphogenesis |
| embryo development |
| negative regulation of cell death |
| response to drug |
| cellular response to oxygen-containing compound |
| nucleobase-containing compound biosynthetic process |
| epithelium development |
| response to abiotic stimulus |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| regulation of programmed cell death |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of immune system process |
| RNA metabolic process |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| macromolecule biosynthetic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| ∆-9-Tetrahydrocannabinol 30μM R08 exp445 | -2.02 |
| 5-Fluorouracil 2μM R00 exp1 | -1.97 |
| Thalidomide 20μM R07 exp406 | -1.95 |
| Rotenone 20μM R00 exp34 | -1.72 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 18/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 2/20 |
| lung | 3/75 |
| lymphocyte | 0/14 |
| ovary | 1/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 2/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7208
- Expression level (log2 read counts): -2.79
Expression Distribution
YAP1 Expression in NALM6 Cells: -2.79
