YBEY [The Human Chemical-Genetic Interaction Map Project]

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======= YBEY =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: YBEY
  * **<color #00a2e8>Official Name</color>**: ybeY metalloendoribonuclease
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54059|54059]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P58557|P58557]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=YBEY&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20YBEY|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617461|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Single strand-specific metallo-endoribonuclease involved in rRNA maturation. {ECO:0000305|PubMed:28153719}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UPF0054|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endoribonuclease activity|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|metalloendopeptidase activity|
|RNA phosphodiester bond hydrolysis|
|rRNA processing|
|rRNA metabolic process|
|nucleic acid phosphodiester bond hydrolysis|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|RNA processing|
|proteolysis|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.71|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.79|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.82|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.82|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.83|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|1.9|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.98|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.06|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|2.12|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.12|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|2.22|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.6|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mcat|MCAT]]|0.515|
|[[:human genes:m:mto1|MTO1]]|0.487|
|[[:human genes:m:mtif2|MTIF2]]|0.459|
|[[:human genes:p:pde12|PDE12]]|0.458|
|[[:human genes:n:nubpl|NUBPL]]|0.446|
|[[:human genes:n:nsun4|NSUN4]]|0.446|
|[[:human genes:p:pet117|PET117]]|0.437|
|[[:human genes:r:rmnd1|RMND1]]|0.427|
|[[:human genes:a:acad9|ACAD9]]|0.413|
|[[:human genes:g:grsf1|GRSF1]]|0.411|
|[[:human genes:m:mettl17|METTL17]]|0.409|
|[[:human genes:r:rexo2|REXO2]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1599
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='YBEY Expression in NALM6 Cells: 3.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>