YBEY

Entrez Summary: N/A
UniProt Summary: Single strand-specific metallo-endoribonuclease involved in rRNA maturation. {ECO:0000305|PubMed:28153719}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BML-284 0.09μM R08 exp460	1.71
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.79
Quercetin 20μM R08 exp517	1.82
YM155 0.0002μM R01 exp61	1.82
CAY10603 0.55μM R08 exp467	1.83
WYE-354 6μM R02 exp90	1.9
Bafilomycin-A1 0.009μM R08 exp454	1.98
Trimetrexate 0.03μM R08 exp535	2.06
5-Fluorouracil 2μM R00 exp1	2.12
Temozolomide 200μM R04 exp189	2.12
Chloroquine 32μM R08 exp470	2.22
Ribavirin 10 to 15μM on day4 R04 exp160	2.6

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

endoribonuclease activity
RNA phosphodiester bond hydrolysis, endonucleolytic
metalloendopeptidase activity
RNA phosphodiester bond hydrolysis
rRNA processing
rRNA metabolic process
nucleic acid phosphodiester bond hydrolysis
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
RNA processing
proteolysis
RNA metabolic process
gene expression