YWHAQ

Gene Information

Official Symbol: YWHAQ
Official Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
Aliases and Previous Symbols: N/A
Entrez ID: 10971
UniProt: P27348
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6897
Expression level (log2 read counts): 8.7

Expression Distribution

Screen	Score
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.95
Colchicine 0.009μM R05 exp215	1.97
Demecolcine 0.03μM R05 exp228	2.89

positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
14-3-3 protein binding
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
substantia nigra development
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
positive regulation of establishment of protein localization to mitochondrion
neural nucleus development
regulation of mitochondrial membrane permeability
regulation of establishment of protein localization to mitochondrion
regulation of membrane permeability
midbrain development
negative regulation of ion transmembrane transport
protein N-terminus binding
positive regulation of mitochondrion organization
negative regulation of transmembrane transport
positive regulation of protein localization to membrane
ion channel binding
mitochondrial membrane organization
negative regulation of ion transport
positive regulation of apoptotic signaling pathway
regulation of mitochondrion organization
regulation of protein localization to membrane
protein C-terminus binding
mitochondrial transport
protein domain specific binding
synapse
small GTPase mediated signal transduction
positive regulation of cellular protein localization
protein targeting
regulation of apoptotic signaling pathway
focal adhesion
mitochondrion organization
positive regulation of establishment of protein localization
regulation of ion transmembrane transport
negative regulation of transport
regulation of cellular protein localization
regulation of transmembrane transport
protein-containing complex
positive regulation of organelle organization