ZC3HC1

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LY2090314 0.003μM R08 exp500 no dilution day6	-2.25
MK2206 4μM R08 exp504	-2.16
Epigallocatechin gallate 20μM R05 exp230	-2.07
LY2090314 0.003μM R08 exp499	-1.98
THZ531 0.11 to 0.125μM on day4 R07 exp410	-1.94
SNS-032 15μM R08 exp443	1.73

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Rsm1
zf-C3HC

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of signal transduction in absence of ligand
regulation of extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of extrinsic apoptotic signaling pathway
regulation of extrinsic apoptotic signaling pathway
negative regulation of apoptotic signaling pathway
nuclear membrane
regulation of apoptotic signaling pathway
protein kinase binding
cell division
protein ubiquitination
protein modification by small protein conjugation
zinc ion binding
negative regulation of apoptotic process
negative regulation of programmed cell death
protein modification by small protein conjugation or removal
negative regulation of cell death
negative regulation of signal transduction
cell cycle
negative regulation of cell communication
negative regulation of signaling
regulation of apoptotic process
regulation of programmed cell death
negative regulation of response to stimulus
regulation of cell death