ZCCHC9

Entrez Summary: N/A
UniProt Summary: May down-regulate transcription mediated by NF-kappa-B and the serum response element. {ECO:0000269|PubMed:18721783}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Milciclib 2μM R08 exp502	-2.1
BN82002 4μM R07 exp340	1.71
NFN1 0.1μM R01 exp49	1.79
Nicotinamide 2000μM R01 exp50	1.79
Docetaxel 0.002μM R01 exp45	2.49
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	2.57

Global Fraction of Cell Lines Where Essential: 9/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	2/75
lymphocyte	1/16
ovary	1/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	1/5

Expression Distribution

negative regulation of phosphatase activity
negative regulation of dephosphorylation
regulation of phosphatase activity
regulation of dephosphorylation
negative regulation of hydrolase activity
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of catalytic activity
zinc ion binding
nucleolus
negative regulation of molecular function
regulation of hydrolase activity
RNA binding
regulation of phosphate metabolic process
regulation of phosphorus metabolic process