ZDHHC21

Entrez Summary: N/A
UniProt Summary: Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity). {ECO:0000250, ECO:0000269|PubMed:22031296}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sebaceous gland development
palmitoyltransferase activity
peptidyl-L-cysteine S-palmitoylation
peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine
protein-cysteine S-palmitoyltransferase activity
protein palmitoylation
peptidyl-cysteine modification
regulation of nitric-oxide synthase activity
regulation of monooxygenase activity
hair follicle development
skin epidermis development
molting cycle process
hair cycle process
protein lipidation
lipoprotein biosynthetic process
hair cycle
molting cycle
regulation of oxidoreductase activity
lipoprotein metabolic process
protein targeting to membrane
protein acylation
establishment of protein localization to membrane
protein targeting
skin development
gland development
epidermis development
protein localization to membrane
Golgi membrane
peptidyl-amino acid modification
Golgi apparatus
intracellular protein transport
endoplasmic reticulum
epithelium development
organonitrogen compound biosynthetic process
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization