ZEB1 [The Human Chemical-Genetic Interaction Map Project]

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======= ZEB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZEB1
  * **<color #00a2e8>Official Name</color>**: zinc finger E-box binding homeobox 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6935|6935]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P37275|P37275]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZEB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZEB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/189909|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|semicircular canal morphogenesis|
|negative regulation of endothelial cell differentiation|
|semicircular canal development|
|cochlea morphogenesis|
|regulation of T cell differentiation in thymus|
|embryonic camera-type eye morphogenesis|
|regulation of smooth muscle cell differentiation|
|regulation of mesenchymal cell proliferation|
|regulation of endothelial cell differentiation|
|embryonic eye morphogenesis|
|embryonic camera-type eye development|
|negative regulation of epithelial cell differentiation|
|E-box binding|
|cochlea development|
|cellular response to amino acid stimulus|
|embryonic skeletal system morphogenesis|
|inner ear morphogenesis|
|camera-type eye morphogenesis|
|regulation of transforming growth factor beta receptor signaling pathway|
|response to amino acid|
|regulation of cellular response to transforming growth factor beta stimulus|
|ear morphogenesis|
|embryonic skeletal system development|
|regulation of T cell differentiation|
|regulation of epithelial cell differentiation|
|eye morphogenesis|
|regulation of muscle cell differentiation|
|regulation of lymphocyte differentiation|
|cartilage development|
|inner ear development|
|transcription factor complex|
|cellular response to acid chemical|
|ear development|
|connective tissue development|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|skeletal system morphogenesis|
|transcription corepressor activity|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|sensory organ morphogenesis|
|regulation of cellular response to growth factor stimulus|
|regulation of leukocyte differentiation|
|transcription coactivator activity|
|embryonic organ morphogenesis|
|camera-type eye development|
|regulation of T cell activation|
|transcription factor binding|
|response to acid chemical|
|eye development|
|visual system development|
|sensory system development|
|positive regulation of neuron differentiation|
|chromatin binding|
|embryonic organ development|
|pattern specification process|
|regulation of hemopoiesis|
|positive regulation of neurogenesis|
|skeletal system development|
|regulation of lymphocyte activation|
|positive regulation of nervous system development|
|positive regulation of cell development|
|sensory organ development|
|embryonic morphogenesis|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|chordate embryonic development|
|regulation of cell activation|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|DNA-binding transcription factor activity|
|negative regulation of cell differentiation|
|regulation of neurogenesis|
|zinc ion binding|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|response to cytokine|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.73|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9905
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZEB1 Expression in NALM6 Cells: 4.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>