ZEB1
Gene Information
- Official Symbol: ZEB1
- Official Name: zinc finger E-box binding homeobox 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 6935
- UniProt: P37275
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| semicircular canal morphogenesis |
| negative regulation of endothelial cell differentiation |
| semicircular canal development |
| cochlea morphogenesis |
| regulation of T cell differentiation in thymus |
| embryonic camera-type eye morphogenesis |
| regulation of smooth muscle cell differentiation |
| regulation of mesenchymal cell proliferation |
| regulation of endothelial cell differentiation |
| embryonic eye morphogenesis |
| embryonic camera-type eye development |
| negative regulation of epithelial cell differentiation |
| E-box binding |
| cochlea development |
| cellular response to amino acid stimulus |
| embryonic skeletal system morphogenesis |
| inner ear morphogenesis |
| camera-type eye morphogenesis |
| regulation of transforming growth factor beta receptor signaling pathway |
| response to amino acid |
| regulation of cellular response to transforming growth factor beta stimulus |
| ear morphogenesis |
| embryonic skeletal system development |
| regulation of T cell differentiation |
| regulation of epithelial cell differentiation |
| eye morphogenesis |
| regulation of muscle cell differentiation |
| regulation of lymphocyte differentiation |
| cartilage development |
| inner ear development |
| transcription factor complex |
| cellular response to acid chemical |
| ear development |
| connective tissue development |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| skeletal system morphogenesis |
| transcription corepressor activity |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| sensory organ morphogenesis |
| regulation of cellular response to growth factor stimulus |
| regulation of leukocyte differentiation |
| transcription coactivator activity |
| embryonic organ morphogenesis |
| camera-type eye development |
| regulation of T cell activation |
| transcription factor binding |
| response to acid chemical |
| eye development |
| visual system development |
| sensory system development |
| positive regulation of neuron differentiation |
| chromatin binding |
| embryonic organ development |
| pattern specification process |
| regulation of hemopoiesis |
| positive regulation of neurogenesis |
| skeletal system development |
| regulation of lymphocyte activation |
| positive regulation of nervous system development |
| positive regulation of cell development |
| sensory organ development |
| embryonic morphogenesis |
| cellular response to organonitrogen compound |
| regulation of leukocyte activation |
| chordate embryonic development |
| regulation of cell activation |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| regulation of neuron differentiation |
| cellular response to nitrogen compound |
| cytokine-mediated signaling pathway |
| negative regulation of cell population proliferation |
| DNA-binding transcription factor activity |
| negative regulation of cell differentiation |
| regulation of neurogenesis |
| zinc ion binding |
| tube development |
| negative regulation of transcription by RNA polymerase II |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| animal organ morphogenesis |
| positive regulation of cell differentiation |
| embryo development |
| central nervous system development |
| response to organonitrogen compound |
| cellular response to cytokine stimulus |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| response to cytokine |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of cell population proliferation |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of immune system process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| THZ1 0.06μM R08 exp531 | -1.73 |
| Isonicotinamide 500μM R03 exp129 | 1.99 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 3/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 2/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9905
- Expression level (log2 read counts): 4.46
Expression Distribution
ZEB1 Expression in NALM6 Cells: 4.46
