ZKSCAN3

Gene Information

Official Symbol: ZKSCAN3
Official Name: zinc finger with KRAB and SCAN domains 3
Aliases and Previous Symbols: N/A
Entrez ID: 80317
UniProt: Q9BRR0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas. {ECO:0000269|PubMed:18940803, ECO:0000269|PubMed:21057542, ECO:0000269|PubMed:22531714, ECO:0000269|PubMed:23434374}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17517
Expression level (log2 read counts): 4.53

Expression Distribution

SCAN
KRAB
zf-C2H2

negative regulation of cellular senescence
negative regulation of cell aging
regulation of cellular senescence
regulation of cell aging
lytic vacuole organization
lysosome organization
negative regulation of autophagy
vacuole organization
DNA-binding transcription repressor activity, RNA polymerase II-specific
negative regulation of cellular catabolic process
process utilizing autophagic mechanism
autophagy
negative regulation of catabolic process
regulation of autophagy
chromatin binding
sequence-specific DNA binding
RNA polymerase II proximal promoter sequence-specific DNA binding
DNA-binding transcription factor activity
regulation of cellular response to stress
regulation of cellular catabolic process
negative regulation of transcription by RNA polymerase II
negative regulation of developmental process
regulation of catabolic process
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
regulation of response to stress
negative regulation of cellular biosynthetic process
positive regulation of transcription, DNA-templated
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
negative regulation of response to stimulus
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
negative regulation of gene expression