ZMYND10

Entrez Summary: This gene encodes a protein containing a MYND-type zinc finger domain that likely functions in assembly of the dynein motor. Mutations in this gene can cause primary ciliary dyskinesia. This gene is also considered a tumor suppressor gene and is often mutated, deleted, or hypermethylated and silenced in cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015].
UniProt Summary: Required for motile ciliary function. Probably involved in axonemal assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins. {ECO:0000269|PubMed:23891469, ECO:0000269|PubMed:23891471}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of motile cilium assembly
positive regulation of motile cilium assembly
inner dynein arm assembly
outer dynein arm assembly
motile cilium assembly
positive regulation of cilium assembly
centriolar satellite
axonemal dynein complex assembly
axoneme assembly
positive regulation of organelle assembly
regulation of cilium assembly
microtubule bundle formation
positive regulation of plasma membrane bounded cell projection assembly
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
regulation of organelle assembly
apical plasma membrane
cilium assembly
cilium organization
positive regulation of cell projection organization
plasma membrane bounded cell projection assembly
cell projection assembly
microtubule cytoskeleton organization
positive regulation of cellular component biogenesis
positive regulation of organelle organization
microtubule-based process
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
organelle assembly
cellular protein-containing complex assembly
regulation of cellular component biogenesis
cytoskeleton organization
plasma membrane bounded cell projection organization
cell projection organization
positive regulation of cellular component organization
regulation of organelle organization
protein-containing complex assembly
protein-containing complex subunit organization