ZNF16

Entrez Summary: N/A
UniProt Summary: Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Plays also a role as an inhibitor of cell apoptosis. {ECO:0000269|PubMed:16628192, ECO:0000269|PubMed:19763908, ECO:0000269|PubMed:21874239}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

response to sodium dodecyl sulfate
cellular response to sodium dodecyl sulfate
positive regulation of megakaryocyte differentiation
cellular response to salt
response to salt
positive regulation of erythrocyte differentiation
regulation of erythrocyte differentiation
regulation of megakaryocyte differentiation
positive regulation of cell division
positive regulation of myeloid cell differentiation
positive regulation of cell cycle phase transition
regulation of cell division
positive regulation of hemopoiesis
regulation of myeloid cell differentiation
positive regulation of cell cycle process
positive regulation of cell cycle
regulation of cell cycle phase transition
regulation of hemopoiesis
cell division
positive regulation of kinase activity
positive regulation of transferase activity
regulation of cell cycle process
nucleolus
regulation of kinase activity
negative regulation of apoptotic process
negative regulation of programmed cell death
positive regulation of cell population proliferation
positive regulation of cell differentiation
regulation of transferase activity
negative regulation of cell death
positive regulation of phosphorylation
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
positive regulation of immune system process
regulation of cell cycle
cell cycle
positive regulation of developmental process
positive regulation of catalytic activity
DNA binding
regulation of apoptotic process