ZNF407 [The Human Chemical-Genetic Interaction Map Project]

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======= ZNF407 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF407
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 407
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55628|55628]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9C0G0|Q9C0G0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF407&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF407|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615894|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a zinc finger protein whose exact function is not known. It may be involved in transcriptional regulation. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in transcriptional regulation.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase II core promoter sequence-specific DNA binding|
|histone methyltransferase complex|
|zinc ion binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.38|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.27|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-2.24|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-2.02|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.97|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 103/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|2/28|
|bone|2/26|
|breast|10/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|6/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|2/21|
|liver|2/20|
|lung|10/75|
|lymphocyte|2/16|
|ovary|4/26|
|pancreas|5/24|
|peripheral nervous system|4/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|6/22|
|urinary tract|5/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2216
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF407 Expression in NALM6 Cells: 5.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>