ZNF431 [The Human Chemical-Genetic Interaction Map Project]

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======= ZNF431 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF431
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 431
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=170959|170959]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TF32|Q8TF32]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF431&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF431|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619505|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein may negatively regulate transcription of target genes, including the hedgehog signaling pathway receptor patched 1, by interacting with histone deacetylases. Mutations in this gene may be associated with non-syndromic facial clefting in human patients. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1 (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KRAB|
|zf-C2H2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of DNA-binding transcription factor activity|
|chromatin binding|
|regulation of DNA-binding transcription factor activity|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-2.48|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-2.36|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.32|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-2.08|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-2|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.89|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|-1.82|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.75|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|1.71|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.71|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.73|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.76|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|1.76|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.81|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|1.82|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.84|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.84|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.86|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|1.86|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.92|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.94|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|1.96|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|2.11|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|2.13|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|2.16|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.17|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.2|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|2.23|
|[[:results:exp149|SB203580 25μM R03 exp149]]|2.66|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6264
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF431 Expression in NALM6 Cells: 6.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>