ZNF431

Entrez Summary: This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein may negatively regulate transcription of target genes, including the hedgehog signaling pathway receptor patched 1, by interacting with histone deacetylases. Mutations in this gene may be associated with non-syndromic facial clefting in human patients. [provided by RefSeq, Jul 2016].
UniProt Summary: Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1 (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
IL-3 9ng/ml R08 exp493	-2.48
Q15 2.7μM R02 exp79	-2.36
Ethanol 0.01 R05 exp234	-2.32
HMS-I2 10μM R06 exp288	-2.08
Dexamethasone 0.006μM R07 exp351	-2
Radicicol 0.16μM R05 exp242	-1.89
DKK1 89ng/ml R08 exp477	-1.82
Etoposide 0.3μM R05 exp199	-1.75
Nicotinamide Riboside 100μM R03 exp139	1.71
Phenformin 20μM R03 exp143	1.71
Dimethyl-Sulfoxide 1pc R03 exp120	1.73
NFN1 0.4μM R03 exp99	1.76
SGC0649 7μM R03 exp150	1.76
Nifuroxazide 5μM R03 exp102	1.81
Dimethyloxaloylglycine 11μM R07 exp314	1.82
All-trans-Retinoic-Acid 40μM R07 exp334	1.84
Staurosporine 0.02μM R08 exp524	1.84
SGC2043 10μM R03 exp152	1.86
VE-822 0.04μM R06 exp300	1.86
UM0125461 0.74μM R02 exp84	1.92
Bafilomycin-A1 0.009μM R08 exp454	1.94
Nicotinamide 2000μM R01 exp50	1.96
TNF-alpha 44ng/ml R08 exp533	2.11
Senexin-A 25μM R07 exp400	2.13
CCT251545 20μM R07 exp326	2.16
BI-6727 0.0125μM R03 exp97	2.17
Ammonium tetrathiomolybdate 10μM R08 exp448	2.2
2-Methoxyestradiol 0.2μM R01 exp40	2.23
SB203580 25μM R03 exp149	2.66

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

KRAB
zf-C2H2

negative regulation of DNA-binding transcription factor activity
chromatin binding
regulation of DNA-binding transcription factor activity
RNA polymerase II proximal promoter sequence-specific DNA binding
negative regulation of transcription by RNA polymerase II
negative regulation of molecular function
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
negative regulation of gene expression