ZNF580 [The Human Chemical-Genetic Interaction Map Project]

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======= ZNF580 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF580
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 580
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51157|51157]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UK33|Q9UK33]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF580&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF580|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617888|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation. {ECO:0000269|PubMed:20382120, ECO:0000269|PubMed:21830064}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C2H2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of interleukin-8 production|
|regulation of interleukin-8 production|
|cellular response to hydrogen peroxide|
|positive regulation of leukocyte chemotaxis|
|positive regulation of endothelial cell proliferation|
|positive regulation of endothelial cell migration|
|regulation of leukocyte chemotaxis|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|positive regulation of leukocyte migration|
|regulation of endothelial cell proliferation|
|cellular response to reactive oxygen species|
|positive regulation of chemotaxis|
|positive regulation of epithelial cell migration|
|regulation of endothelial cell migration|
|positive regulation of epithelial cell proliferation|
|response to reactive oxygen species|
|regulation of leukocyte migration|
|regulation of chemotaxis|
|cellular response to toxic substance|
|regulation of epithelial cell migration|
|cellular response to oxidative stress|
|response to antibiotic|
|regulation of epithelial cell proliferation|
|response to oxidative stress|
|cellular response to drug|
|positive regulation of cytokine production|
|inflammatory response|
|positive regulation of cell migration|
|response to toxic substance|
|positive regulation of cell motility|
|response to inorganic substance|
|positive regulation of cellular component movement|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|positive regulation of response to external stimulus|
|regulation of cytokine production|
|regulation of cell migration|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of locomotion|
|regulation of cellular component movement|
|response to drug|
|cellular response to oxygen-containing compound|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|locomotion|
|defense response|
|DNA binding|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|regulation of immune system process|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|-1.75|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|1.85|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.94|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11668
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF580 Expression in NALM6 Cells: 3.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>