ZNF580

Entrez Summary: N/A
UniProt Summary: Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation. {ECO:0000269|PubMed:20382120, ECO:0000269|PubMed:21830064}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of interleukin-8 production
regulation of interleukin-8 production
cellular response to hydrogen peroxide
positive regulation of leukocyte chemotaxis
positive regulation of endothelial cell proliferation
positive regulation of endothelial cell migration
regulation of leukocyte chemotaxis
cellular response to antibiotic
response to hydrogen peroxide
positive regulation of leukocyte migration
regulation of endothelial cell proliferation
cellular response to reactive oxygen species
positive regulation of chemotaxis
positive regulation of epithelial cell migration
regulation of endothelial cell migration
positive regulation of epithelial cell proliferation
response to reactive oxygen species
regulation of leukocyte migration
regulation of chemotaxis
cellular response to toxic substance
regulation of epithelial cell migration
cellular response to oxidative stress
response to antibiotic
regulation of epithelial cell proliferation
response to oxidative stress
cellular response to drug
positive regulation of cytokine production
inflammatory response
positive regulation of cell migration
response to toxic substance
positive regulation of cell motility
response to inorganic substance
positive regulation of cellular component movement
chemotaxis
taxis
positive regulation of locomotion
positive regulation of response to external stimulus
regulation of cytokine production
regulation of cell migration
regulation of cell motility