ZNF608 [The Human Chemical-Genetic Interaction Map Project]

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======= ZNF608 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF608
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 608
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57507|57507]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9ULD9|Q9ULD9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF608&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF608|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620972|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor, which represses ZNF609 transcription. {ECO:0000250|UniProtKB:Q56A10}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleic acid binding|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-2.6|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2.16|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-2.14|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.02|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.92|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.9|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.73|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.71|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.71|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.72|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.07|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.28|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|3.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.722|
|[[:human genes:t:tle4|TLE4]]|0.57|
|[[:human genes:o:otud5|OTUD5]]|0.525|
|[[:human genes:r:rptor|RPTOR]]|0.518|
|[[:human genes:m:mllt1|MLLT1]]|0.516|
|[[:human genes:t:trim28|TRIM28]]|0.5|
|[[:human genes:g:gmppb|GMPPB]]|0.488|
|[[:human genes:m:meaf6|MEAF6]]|0.46|
|[[:human genes:r:rtcb|RTCB]]|0.457|
|[[:human genes:t:thg1l|THG1L]]|0.451|
|[[:human genes:z:znf592|ZNF592]]|0.45|
|[[:human genes:g:gfpt1|GFPT1]]|0.447|
|[[:human genes:n:nsd1|NSD1]]|0.443|
|[[:human genes:e:eif4e|EIF4E]]|0.442|
|[[:human genes:c:ccdc101|CCDC101]]|0.439|
|[[:human genes:h:hmgb2|HMGB2]]|0.437|
|[[:human genes:b:bap1|BAP1]]|0.437|
|[[:human genes:u:ubr5|UBR5]]|0.436|
|[[:human genes:m:mtor|MTOR]]|0.435|
|[[:human genes:i:id3|ID3]]|0.432|
|[[:human genes:t:trmt5|TRMT5]]|0.428|
|[[:human genes:m:mars|MARS]]|0.427|
|[[:human genes:t:tti2|TTI2]]|0.427|
|[[:human genes:u:ube2g1|UBE2G1]]|0.426|
|[[:human genes:r:rere|RERE]]|0.422|
|[[:human genes:p:pdap1|PDAP1]]|0.422|
|[[:human genes:c:csnk2b|CSNK2B]]|0.42|
|[[:human genes:w:wdr24|WDR24]]|0.418|
|[[:human genes:v:vmp1|VMP1]]|0.416|
|[[:human genes:p:pmm2|PMM2]]|0.411|
|[[:human genes:p:pam16|PAM16]]|0.407|
|[[:human genes:m:med23|MED23]]|0.407|
|[[:human genes:l:lsm11|LSM11]]|0.402|
|[[:human genes:b:brpf1|BRPF1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3116
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.1 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF608 Expression in NALM6 Cells: 8.1'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>